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    HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717177, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HECTD1provided by VGNC
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:73200
    See related
    Ensembl:ENSMMUG00000003120
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HECTD1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (93196195..93308312, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (92501553..92613869, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene striatin 3 Neighboring gene intraflagellar transport protein 20 homolog pseudogene Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene U6 spliceosomal RNA Neighboring gene asparagine--tRNA ligase, cytoplasmic pseudogene Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial pseudogene Neighboring gene HEAT repeat containing 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECTD1
    Names
    HECT domain containing 1
    NP_001248188.1
    XP_014998967.1
    XP_014998968.1
    XP_014998969.1
    XP_014998970.1
    XP_014998971.1
    XP_014998972.1
    XP_028706381.1
    XP_028706382.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261259.2 → NP_001248188.1  E3 ubiquitin-protein ligase HECTD1

      See identical proteins and their annotated locations for NP_001248188.1

      Status: PROVISIONAL

      Source sequence(s)
      JU472233
      UniProtKB/TrEMBL
      F6XN59, F7DL51, H9FSK0
      Related
      ENSMMUP00000065836.1, ENSMMUT00000080052.1
      Conserved Domains (6) summary
      cd00078
      Location:2131 → 2608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1892 → 1965
      BTHB; Basic tilted helix bundle domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      93196195..93308312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015143482.2 → XP_014998968.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

      UniProtKB/TrEMBL
      F6XN59, F7DL51, H9FSK0
      Conserved Domains (6) summary
      cd00078
      Location:2131 → 2608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1892 → 1965
      BTHB; Basic tilted helix bundle domain

    2. XM_015143486.2 → XP_014998972.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      Conserved Domains (6) summary
      cd00078
      Location:1852 → 2329
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1302
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1613 → 1686
      BTHB; Basic tilted helix bundle domain

    3. XM_028850549.1 → XP_028706382.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      F7DL51
      Conserved Domains (6) summary
      cd00078
      Location:2082 → 2559
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1321
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1843 → 1916
      BTHB; Basic tilted helix bundle domain

    4. XM_015143484.2 → XP_014998970.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      F7DL51
      Conserved Domains (6) summary
      cd00078
      Location:2084 → 2561
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1321
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1845 → 1918
      BTHB; Basic tilted helix bundle domain

    5. XM_015143483.2 → XP_014998969.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      F7DL51, H9FSK1
      Conserved Domains (6) summary
      cd00078
      Location:2129 → 2606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1890 → 1963
      BTHB; Basic tilted helix bundle domain

    6. XM_015143485.2 → XP_014998971.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      A0A5F8AKA2, F7DL51
      Related
      ENSMMUP00000077446.1, ENSMMUT00000097081.1
      Conserved Domains (5) summary
      cd00078
      Location:2070 → 2547
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_015143481.2 → XP_014998967.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

      UniProtKB/TrEMBL
      F6XN59, F7DL51, H9FSK0
      Related
      ENSMMUP00000033002.2, ENSMMUT00000039940.3
      Conserved Domains (6) summary
      cd00078
      Location:2131 → 2608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1892 → 1965
      BTHB; Basic tilted helix bundle domain

    8. XM_028850548.1 → XP_028706381.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

      UniProtKB/TrEMBL
      F7DL51
      Conserved Domains (5) summary
      cd00078
      Location:2091 → 2568
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:356 → 386
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1237 → 1295
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1067 → 1200
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:326 → 417
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version

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