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    TRIM50 tripartite motif containing 50 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 716264, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TRIM50provided by VGNC
    Official Full Name
    tripartite motif containing 50provided by VGNC
    Primary source
    VGNC:VGNC:81781
    Locus tag
    EGK_13591
    See related
    Ensembl:ENSMMUG00000022778
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TRIM50 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (45659674..45673264, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (41873097..41889662, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene POM121 transmembrane nucleoporin C Neighboring gene uncharacterized LOC106997355 Neighboring gene NOP2/Sun RNA methyltransferase 5 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene uncharacterized LOC114676880 Neighboring gene U6 spliceosomal RNA Neighboring gene FKBP prolyl isomerase family member 6 (inactive)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM50
    XP_001110857.1
    XP_028701505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      45659674..45673264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028845672.1 → XP_028701505.1  E3 ubiquitin-protein ligase TRIM50 isoform X2

      Conserved Domains (3) summary
      cd00021
      Location:91 → 126
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd16605
      Location:14 → 58
      RING-HC_TRIM50_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM50, TRIM73, TRIM74 and similar proteins
      cl02614
      Location:283 → 470
      SPRY; SPRY domain

    2. XM_001110857.4 → XP_001110857.1  E3 ubiquitin-protein ligase TRIM50 isoform X1

      See identical proteins and their annotated locations for XP_001110857.1

      UniProtKB/TrEMBL
      A0A1D5QSV8, A0A8J8XGW7, F7G8Y0, G7MNZ6
      Related
      ENSMMUP00000029989.4, ENSMMUT00000032052.4
      Conserved Domains (4) summary
      cd00021
      Location:91 → 126
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl02614
      Location:284 → 471
      SPRY; SPRY domain
      cl17238
      Location:16 → 56
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:135 → 258
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein
    Heading Accession and Version

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