GRB10 growth factor receptor bound protein 10 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: GRB10provided by VGNC
Official Full Name: growth factor receptor bound protein 10provided by VGNC
Primary source: VGNC:VGNC:73157
Locus tag: EGK_13690
See related: Ensembl:ENSMMUG00000019992
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	3	NC_041756.1 (64496981..64700110)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	3	NC_027895.1 (57901086..58104637)

Chromosome 3 - NC_041756.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

SHGC-52576 (e-PCR)
- UniSTS:90652

RH11858 (e-PCR)
- UniSTS:76596

GDB:6028674 (e-PCR)
- UniSTS:44100

D7S3125 (e-PCR)
- UniSTS:186692

GDB:1317480 (e-PCR)
- UniSTS:39756

D7S2137E (e-PCR)
- UniSTS:151135

SHGC-23058 (e-PCR)
- UniSTS:41826

MARC_51491-51492:1152645911:1 (e-PCR)
- UniSTS:508091

WI-14569 (e-PCR)
- UniSTS:81096

GRB10_964 (e-PCR)
- UniSTS:468449

GRB10_V246 (e-PCR)
- UniSTS:468449

SHGC-79976 (e-PCR)
- UniSTS:101609

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth factor receptor-bound protein 10

Names: GRB10 adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001257428.1 → NP_001244357.1 growth factor receptor-bound protein 10

See identical proteins and their annotated locations for NP_001244357.1

Status: PROVISIONAL

Source sequence(s)

JU334129

UniProtKB/TrEMBL

A0A1D5QVU3, A0A8J8XUH0, G7MLA7

Related

ENSMMUP00000052173.1, ENSMMUT00000073956.2

Conserved Domains (4) summary

cd10415
Location:486 → 593

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:285 → 407

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:165 → 256

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:425 → 466

BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041756.1 Reference Mmul_10 Primary Assembly

Range

64496981..64700110

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015133490.2 → XP_014988976.1 growth factor receptor-bound protein 10 isoform X1

Conserved Domains (4) summary

cd10415
Location:428 → 535

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)
XM_015133487.2 → XP_014988973.1 growth factor receptor-bound protein 10 isoform X6

Conserved Domains (4) summary

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

cl15255
Location:428 → 491

SH2; Src homology 2 (SH2) domain
XM_028844791.1 → XP_028700624.1 growth factor receptor-bound protein 10 isoform X5

UniProtKB/TrEMBL

A0A1D5QVU3, A0A8J8XUH0, G7MLA7

Conserved Domains (4) summary

cd10415
Location:486 → 593

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:285 → 407

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:165 → 256

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:425 → 466

BPS; BPS (Between PH and SH2)
XM_015133478.2 → XP_014988964.1 growth factor receptor-bound protein 10 isoform X3

Conserved Domains (5) summary

cd01787
Location:165 → 247

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd01259
Location:285 → 407

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam00169
Location:290 → 398

PH; PH domain

pfam08947
Location:425 → 466

BPS; BPS (Between PH and SH2)

cl15255
Location:486 → 549

SH2; Src homology 2 (SH2) domain
XM_015133488.2 → XP_014988974.1 growth factor receptor-bound protein 10 isoform X6

Conserved Domains (4) summary

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

cl15255
Location:428 → 491

SH2; Src homology 2 (SH2) domain
XM_028844797.1 → XP_028700630.1 growth factor receptor-bound protein 10 isoform X7

UniProtKB/TrEMBL

F7FNV0

Related

ENSMMUP00000026288.4, ENSMMUT00000028098.4

Conserved Domains (4) summary

cd10415
Location:524 → 631

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:323 → 445

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:463 → 504

BPS; BPS (Between PH and SH2)

cd16141
Location:203 → 294

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
XM_028844790.1 → XP_028700623.1 growth factor receptor-bound protein 10 isoform X2

Conserved Domains (4) summary

cd10415
Location:535 → 642

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:334 → 456

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:474 → 515

BPS; BPS (Between PH and SH2)

cd16141
Location:214 → 305

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
XM_015133477.2 → XP_014988963.1 growth factor receptor-bound protein 10 isoform X3

Conserved Domains (5) summary

cd01787
Location:165 → 247

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd01259
Location:285 → 407

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam00169
Location:290 → 398

PH; PH domain

pfam08947
Location:425 → 466

BPS; BPS (Between PH and SH2)

cl15255
Location:486 → 549

SH2; Src homology 2 (SH2) domain
XM_028844793.1 → XP_028700626.1 growth factor receptor-bound protein 10 isoform X6

Conserved Domains (4) summary

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

cl15255
Location:428 → 491

SH2; Src homology 2 (SH2) domain
XM_028844795.1 → XP_028700628.1 growth factor receptor-bound protein 10 isoform X1

Conserved Domains (4) summary

cd10415
Location:428 → 535

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)
XM_028844796.1 → XP_028700629.1 growth factor receptor-bound protein 10 isoform X6

Conserved Domains (4) summary

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

cl15255
Location:428 → 491

SH2; Src homology 2 (SH2) domain
XM_028844794.1 → XP_028700627.1 growth factor receptor-bound protein 10 isoform X1

Conserved Domains (4) summary

cd10415
Location:428 → 535

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)
XM_028844792.1 → XP_028700625.1 growth factor receptor-bound protein 10 isoform X6

Conserved Domains (4) summary

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

cl15255
Location:428 → 491

SH2; Src homology 2 (SH2) domain
XM_015133482.2 → XP_014988968.1 growth factor receptor-bound protein 10 isoform X4

UniProtKB/TrEMBL

F7F404

Related

ENSMMUP00000035307.3, ENSMMUT00000042308.3

Conserved Domains (5) summary

cd01787
Location:149 → 231

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd01259
Location:269 → 391

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam00169
Location:274 → 382

PH; PH domain

pfam08947
Location:409 → 450

BPS; BPS (Between PH and SH2)

cl15255
Location:470 → 533

SH2; Src homology 2 (SH2) domain
XM_028844789.1 → XP_028700622.1 growth factor receptor-bound protein 10 isoform X1

Conserved Domains (4) summary

cd10415
Location:428 → 535

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:227 → 349

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:107 → 198

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:367 → 408

BPS; BPS (Between PH and SH2)