SMURF2 SMAD specific E3 ubiquitin protein ligase 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SMURF2provided by VGNC
Official Full Name: SMAD specific E3 ubiquitin protein ligase 2provided by VGNC
Primary source: VGNC:VGNC:77727
See related: Ensembl:ENSMMUG00000009461
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	16	NC_041769.1 (61087556..61205393, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	16	NC_027908.1 (58163203..58281806, complement)

Chromosome 16 - NC_041769.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results provide the evidence that Smurf2 may play specific roles in glandular secretion, trophoblastic cell invasion, and placentation through mediating the expression of the related proteins of TGF-beta signaling pathway during early pregnancy
Title: Expression of Smad ubiquitin regulatory factor 2 (Smurf2) in rhesus monkey endometrium and placenta during early pregnancy.

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General gene information

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Markers

RH75179 (e-PCR)
- UniSTS:92964

STS-T85104 (e-PCR)
- UniSTS:5273

RH79618 (e-PCR)
- UniSTS:88744

Smurf2 (e-PCR), detects polymorphism
- UniSTS:527558

SMURF2__6867 (e-PCR)
- UniSTS:471767

RH79788 (e-PCR)
- UniSTS:86247

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SMURF2

XP_014975605.1

EC 2.3.2.26

XP_014975606.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041769.1 Reference Mmul_10 Primary Assembly

Range

61087556..61205393 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015120119.2 → XP_014975605.1 E3 ubiquitin-protein ligase SMURF2 isoform X1

UniProtKB/TrEMBL

A0A5F8AG48, H9F9P8

Related

ENSMMUP00000075947.1, ENSMMUT00000083162.1

Conserved Domains (5) summary

cd08382
Location:13 → 137

C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins

smart00456
Location:298 → 330

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:420 → 745

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:393 → 745

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:159 → 188

WW; WW domain
XM_015120120.2 → XP_014975606.1 E3 ubiquitin-protein ligase SMURF2 isoform X2

UniProtKB/TrEMBL

A0A5F8A5F8, H9F9P8

Related

ENSMMUP00000072597.1, ENSMMUT00000110374.1

Conserved Domains (5) summary

cd08382
Location:19 → 124

C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins

smart00456
Location:285 → 317

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:407 → 732

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:380 → 732

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:146 → 175

WW; WW domain