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    KMT2D lysine methyltransferase 2D [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710795, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KMT2Dprovided by VGNC
    Official Full Name
    lysine methyltransferase 2Dprovided by VGNC
    Primary source
    VGNC:VGNC:74273
    See related
    Ensembl:ENSMMUG00000015718
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    MLL2
    Orthologs
    human mouse all
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    Genomic context

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    See KMT2D in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (48628136..48670741, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (47310427..47350683, complement)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene uncharacterized LOC107000858 Neighboring gene RHEB like 1 Neighboring gene desert hedgehog signaling molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2D
    Names
    myeloid/lymphoid or mixed-lineage leukemia 2
    XP_015007133.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      48628136..48670741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015151647.2 → XP_015007133.2  histone-lysine N-methyltransferase 2D

      UniProtKB/TrEMBL
      G7N6V7
      Related
      ENSMMUP00000020643.4, ENSMMUT00000022067.4
      Conserved Domains (13) summary
      smart00398
      Location:2039 → 2090
      HMG; high mobility group
      smart00542
      Location:5260 → 5347
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5417 → 5539
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:5541 → 5557
      PostSET; Cysteine-rich motif following a subset of SET domains
      PHA03247
      Location:691 → 1216
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1447 → 1493
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1396 → 1446
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1524 → 1574
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5052 → 5158
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam05964
      Location:5201 → 5252
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version

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