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    MACF1 microtubule actin crosslinking factor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718651, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MACF1provided by VGNC
    Official Full Name
    microtubule actin crosslinking factor 1provided by VGNC
    Primary source
    VGNC:VGNC:100006
    See related
    Ensembl:ENSMMUG00000009562
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MACF1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    106
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (185094542..185502771, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (38342855..38760960)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114672987 Neighboring gene succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial Neighboring gene bone morphogenetic protein 8B Neighboring gene uncharacterized LOC114672989 Neighboring gene U6 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 Neighboring gene akirin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intermediate filament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-actin cross-linking factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      185094542..185502771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028835657.1 → XP_028691490.1  microtubule-actin cross-linking factor 1 isoform X17

      UniProtKB/TrEMBL
      A0A1D5RFN3, F6X558
      Related
      ENSMMUP00000012513.4, ENSMMUT00000013356.4
      Conserved Domains (9) summary
      smart00243
      Location:5162 → 5234
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:4929 → 5053
      SPEC; Spectrin repeats
      COG1196
      Location:2125 → 2965
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:73 → 297
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:4267 → 4483
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2866 → 3745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1628 → 1843
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05956
      Location:5251 → 5428
      APC_basic; APC basic domain
      pfam13499
      Location:5085 → 5148
      EF-hand_7; EF-hand domain pair

    2. XM_015135829.2 → XP_014991315.2  microtubule-actin cross-linking factor 1 isoform X6

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (9) summary
      smart00150
      Location:5070 → 5194
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3106
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4408 → 4624
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2956 → 3886
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1790 → 2005
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam02187
      Location:5310 → 5384
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5499 → 5640
      APC_basic; APC basic domain
      pfam13499
      Location:5231 → 5294
      EF-hand_7; EF-hand domain pair

    3. XM_028835650.1 → XP_028691483.1  microtubule-actin cross-linking factor 1 isoform X14

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00150
      Location:4982 → 5106
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4320 → 4536
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3798
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:5222 → 5296
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5411 → 5552
      APC_basic; APC basic domain
      pfam13499
      Location:5143 → 5206
      EF-hand_7; EF-hand domain pair

    4. XM_028835616.1 → XP_028691449.1  microtubule-actin cross-linking factor 1 isoform X3

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00150
      Location:5088 → 5212
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4426 → 4642
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:5328 → 5402
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5517 → 5658
      APC_basic; APC basic domain
      pfam13499
      Location:5249 → 5312
      EF-hand_7; EF-hand domain pair

    5. XM_028835615.1 → XP_028691448.1  microtubule-actin cross-linking factor 1 isoform X2

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:5330 → 5404
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5519 → 5660
      APC_basic; APC basic domain
      pfam13499
      Location:5251 → 5314
      EF-hand_7; EF-hand domain pair

    6. XM_015135828.2 → XP_014991314.2  microtubule-actin cross-linking factor 1 isoform X4

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:5331 → 5399
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5514 → 5655
      APC_basic; APC basic domain
      pfam13499
      Location:5252 → 5315
      EF-hand_7; EF-hand domain pair

    7. XM_015135837.2 → XP_014991323.2  microtubule-actin cross-linking factor 1 isoform X15

      UniProtKB/TrEMBL
      H9F7C6
      Conserved Domains (8) summary
      smart00243
      Location:5329 → 5407
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1790 → 2005
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam13499
      Location:5252 → 5315
      EF-hand_7; EF-hand domain pair

    8. XM_015135827.2 → XP_014991313.2  microtubule-actin cross-linking factor 1 isoform X1

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:5331 → 5405
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5520 → 5661
      APC_basic; APC basic domain
      pfam13499
      Location:5252 → 5315
      EF-hand_7; EF-hand domain pair

    9. XM_015135831.2 → XP_014991317.2  microtubule-actin cross-linking factor 1 isoform X8

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00243
      Location:5329 → 5401
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05956
      Location:5491 → 5632
      APC_basic; APC basic domain
      pfam13499
      Location:5252 → 5315
      EF-hand_7; EF-hand domain pair

    10. XM_015135830.2 → XP_014991316.2  microtubule-actin cross-linking factor 1 isoform X7

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00243
      Location:5329 → 5407
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05956
      Location:5497 → 5638
      APC_basic; APC basic domain
      pfam13499
      Location:5252 → 5315
      EF-hand_7; EF-hand domain pair

    11. XM_028835624.1 → XP_028691457.1  microtubule-actin cross-linking factor 1 isoform X5

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:5326 → 5394
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5509 → 5650
      APC_basic; APC basic domain
      pfam13499
      Location:5247 → 5310
      EF-hand_7; EF-hand domain pair

    12. XM_028835636.1 → XP_028691469.1  microtubule-actin cross-linking factor 1 isoform X9

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00243
      Location:5324 → 5396
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05956
      Location:5486 → 5627
      APC_basic; APC basic domain
      pfam13499
      Location:5247 → 5310
      EF-hand_7; EF-hand domain pair

    13. XM_028835645.1 → XP_028691478.1  microtubule-actin cross-linking factor 1 isoform X12

      UniProtKB/TrEMBL
      H9F7C6
      Conserved Domains (9) summary
      smart00243
      Location:5329 → 5401
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1790 → 2005
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05956
      Location:5418 → 5595
      APC_basic; APC basic domain
      pfam13499
      Location:5252 → 5315
      EF-hand_7; EF-hand domain pair

    14. XM_028835670.1 → XP_028691503.1  microtubule-actin cross-linking factor 1 isoform X20

      Conserved Domains (8) summary
      smart00150
      Location:3825 → 3949
      SPEC; Spectrin repeats
      COG0419
      Location:198 → 739
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1021 → 1861
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:3163 → 3379
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1762 → 2641
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02187
      Location:4065 → 4139
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:4254 → 4395
      APC_basic; APC basic domain
      pfam13499
      Location:3986 → 4049
      EF-hand_7; EF-hand domain pair

    15. XM_028835679.1 → XP_028691512.1  microtubule-actin cross-linking factor 1 isoform X21

      Conserved Domains (6) summary
      smart00243
      Location:3210 → 3285
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:2972 → 3096
      SPEC; Spectrin repeats
      PHA03247
      Location:834 → 1221
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:3368 → 3542
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00176
      Location:2310 → 2526
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam13499
      Location:3133 → 3196
      EF-hand_7; EF-hand domain pair

    16. XM_028835661.1 → XP_028691494.1  microtubule-actin cross-linking factor 1 isoform X18

      UniProtKB/TrEMBL
      A0A1D5RFN3
      Related
      ENSMMUP00000045947.2, ENSMMUT00000075882.2
      Conserved Domains (9) summary
      smart00243
      Location:5141 → 5213
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:4908 → 5032
      SPEC; Spectrin repeats
      COG1196
      Location:2125 → 2944
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:73 → 297
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:4246 → 4462
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2845 → 3724
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1628 → 1843
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05956
      Location:5230 → 5407
      APC_basic; APC basic domain
      pfam13499
      Location:5064 → 5127
      EF-hand_7; EF-hand domain pair

    17. XM_028835665.1 → XP_028691498.1  microtubule-actin cross-linking factor 1 isoform X19

      UniProtKB/TrEMBL
      A0A1D5RFN3
      Related
      ENSMMUP00000059127.2, ENSMMUT00000071552.2
      Conserved Domains (9) summary
      smart00243
      Location:5054 → 5132
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:4817 → 4941
      SPEC; Spectrin repeats
      COG1196
      Location:2125 → 2965
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:73 → 297
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:4155 → 4371
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2815 → 3636
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1628 → 1843
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05956
      Location:5149 → 5326
      APC_basic; APC basic domain
      pfam13499
      Location:4977 → 5040
      EF-hand_7; EF-hand domain pair

    18. XM_028835640.1 → XP_028691473.1  microtubule-actin cross-linking factor 1 isoform X11

      UniProtKB/TrEMBL
      H9F7C6
      Conserved Domains (9) summary
      smart00243
      Location:5328 → 5406
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1790 → 2005
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05956
      Location:5423 → 5600
      APC_basic; APC basic domain
      pfam13499
      Location:5251 → 5314
      EF-hand_7; EF-hand domain pair

    19. XM_015135840.2 → XP_014991326.2  microtubule-actin cross-linking factor 1 isoform X16

      UniProtKB/TrEMBL
      H9F7C6
      Conserved Domains (9) summary
      smart00243
      Location:5194 → 5266
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:4961 → 5085
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3106
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4299 → 4515
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2956 → 3777
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1790 → 2005
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05956
      Location:5283 → 5460
      APC_basic; APC basic domain
      pfam13499
      Location:5117 → 5180
      EF-hand_7; EF-hand domain pair

    20. XM_028835648.1 → XP_028691481.1  microtubule-actin cross-linking factor 1 isoform X13

      UniProtKB/TrEMBL
      H9F7C6
      Conserved Domains (9) summary
      smart00243
      Location:5324 → 5396
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1790 → 2005
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05956
      Location:5413 → 5590
      APC_basic; APC basic domain
      pfam13499
      Location:5247 → 5310
      EF-hand_7; EF-hand domain pair

    21. XM_028835639.1 → XP_028691472.1  microtubule-actin cross-linking factor 1 isoform X10

      UniProtKB/TrEMBL
      H9F7C6
      Conserved Domains (9) summary
      smart00150
      Location:5091 → 5215
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4429 → 4645
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:1790 → 2005
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam02187
      Location:5326 → 5394
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      pfam05956
      Location:5436 → 5613
      APC_basic; APC basic domain
      pfam13499
      Location:5247 → 5310
      EF-hand_7; EF-hand domain pair

    22. XM_015135858.2 → XP_014991344.2  microtubule-actin cross-linking factor 1 isoform X22

      UniProtKB/TrEMBL
      F6X576
      Conserved Domains (8) summary
      smart00243
      Location:5321 → 5399
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      smart00150
      Location:5088 → 5212
      SPEC; Spectrin repeats
      COG1196
      Location:2287 → 3127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:355 → 458
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:4426 → 4642
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:2977 → 3907
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05956
      Location:5489 → 5630
      APC_basic; APC basic domain
      pfam13499
      Location:5244 → 5307
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version

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