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    ZNF28 zinc finger protein 28 [ Homo sapiens (human) ]

    Gene ID: 7576, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF28provided by HGNC
    Official Full Name
    zinc finger protein 28provided by HGNC
    Primary source
    HGNC:HGNC:13073
    See related
    Ensembl:ENSG00000198538 MIM:620466; AllianceGenome:HGNC:13073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX24
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.8), colon (RPKM 1.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF28 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52797408..52821633, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55881862..55905963, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53300661..53324886, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 611 Neighboring gene uncharacterized LOC124904760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53238285-53239270 Neighboring gene uncharacterized LOC105372452 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53259364-53260079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53263091-53263641 Neighboring gene zinc finger protein 600 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53285228-53285408 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53287129-53287305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289004-53289862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289863-53290720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53293023-53293553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53294085-53294614 Neighboring gene PABPN1 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53324831-53325332 Neighboring gene zinc finger protein 468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15057 Neighboring gene zinc finger protein 320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53379555-53380056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Rousseau-Merck MF, et al. Hum Genet, 1993 Dec. PMID 8262519
    2. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
    3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
    4. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
    5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781D0275

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 28
    Names
    zinc finger protein KOX24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369761.1 → NP_001356690.1  zinc finger protein 28 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008813
      Consensus CDS
      CCDS92677.1
      UniProtKB/TrEMBL
      M0QXU3
      Related
      ENSP00000469381.1, ENST00000594602.5
      Conserved Domains (1) summary
      smart00349
      Location:8 → 54
      KRAB; krueppel associated box

    2. NM_001369762.1 → NP_001356691.1  zinc finger protein 28 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008813
      Consensus CDS
      CCDS92676.1
      Related
      ENSP00000375661.2, ENST00000391783.6
      Conserved Domains (3) summary
      COG5048
      Location:300 → 661
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:211 → 321
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001369763.1 → NP_001356692.1  zinc finger protein 28 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008813
      Conserved Domains (3) summary
      COG5048
      Location:350 → 711
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:261 → 371
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:550 → 570
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001369764.1 → NP_001356693.1  zinc finger protein 28 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008813
      Conserved Domains (4) summary
      COG5048
      Location:339 → 700
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:250 → 360
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:539 → 559
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    5. NM_001369765.1 → NP_001356694.1  zinc finger protein 28 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008813
      Conserved Domains (3) summary
      COG5048
      Location:317 → 678
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:228 → 338
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001369766.1 → NP_001356695.1  zinc finger protein 28 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC008813
      Conserved Domains (1) summary
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    7. NM_001369767.1 → NP_001356696.1  zinc finger protein 28 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC008813

    8. NM_001369768.1 → NP_001356697.1  zinc finger protein 28 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC008813, BC070146
      UniProtKB/TrEMBL
      Q6NSH2
      Related
      ENST00000464469.2
      Conserved Domains (1) summary
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    9. NM_006969.5 → NP_008900.3  zinc finger protein 28 isoform 1

      See identical proteins and their annotated locations for NP_008900.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC008813
      Consensus CDS
      CCDS33093.2
      UniProtKB/Swiss-Prot
      A8KAK9, B4E3G0, B9EIK7, P17035, Q5H9V1, Q5HYM9, Q6ZML9, Q6ZN56
      Related
      ENSP00000397693.2, ENST00000457749.7
      Conserved Domains (5) summary
      smart00349
      Location:8 → 48
      KRAB; krueppel associated box
      COG5048
      Location:267 → 655
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553 → 573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:397 → 422
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_163139.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008813

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52797408..52821633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55881862..55905963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17035.5 GenPept UniProtKB/Swiss-Prot:P17035

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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