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    fmo5 flavin containing dimethylaniline monoxygenase 5 [ Danio rerio (zebrafish) ]

    Gene ID: 794311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fmo5provided by ZNC
    Official Full Name
    flavin containing dimethylaniline monoxygenase 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6606
    See related
    Ensembl:ENSDARG00000016357 AllianceGenome:ZFIN:ZDB-GENE-030131-6606
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb1007; wu:fc05b01; wu:fk47g04
    Summary
    Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including ectoderm; epidermis; intestinal bulb primordium; presumptive ectoderm; and pronephric duct. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fmo5 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (15093618..15104690, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (15194115..15205187, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene si:dkey-239i20.2 Neighboring gene si:dkey-239i20.4 Neighboring gene phospholipid phosphatase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Li ZH, et al. Mol Biosyst, 2011 Jul. PMID 21445457
    2. Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Singh SK, et al. Fish Shellfish Immunol, 2014 Sep. PMID 25014315
    3. Selection of reliable biomarkers from PCR array analyses using relative distance computational model: methodology and proof-of-concept study. Liu C, et al. PLoS One, 2013. PMID 24349563, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC65839, MGC162406, MGC174986

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 5
    Names
    flavin containing monooxygenase 5
    NP_944592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198910.1 → NP_944592.1  dimethylaniline monooxygenase [N-oxide-forming] 5

      See identical proteins and their annotated locations for NP_944592.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055385
      UniProtKB/TrEMBL
      A0A2R8Q144, F6NWZ0, Q7T1D7
      Related
      ENSDARP00000038651.5, ENSDART00000034011.6
      Conserved Domains (2) summary
      pfam00743
      Location:2 → 531
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:7 → 150
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      15093618..15104690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395065.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      48102..59174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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