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    Cox7a2 cytochrome c oxidase subunit 7A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox7a2provided by RGD
    Official Full Name
    cytochrome c oxidase subunit 7A2provided by RGD
    Primary source
    RGD:68365
    See related
    EnsemblRapid:ENSRNOG00000042903 AllianceGenome:RGD:68365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cox7a3
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex. Orthologous to several human genes including COX7A2 (cytochrome c oxidase subunit 7A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 6460.7), Muscle (RPKM 4016.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox7a2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (89597051..89611032, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (80716824..80720922, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (87209529..87213627, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene Sec61 translocon subunit gamma like 1 Neighboring gene transmembrane protein 30A Neighboring gene filamin A interacting protein 1 Neighboring gene uncharacterized LOC134480210 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of cDNA encoding subunit VIIa of rat liver cytochrome c oxidase. Enders C, et al. Nucleic Acids Res, 1990 Dec 11. PMID 2175887, Free PMC Article
    2. Isoforms of mammalian cytochrome c oxidase: correlation with human cytochrome c oxidase deficiency. Kennaway NG, et al. Pediatr Res, 1990 Nov. PMID 2175025
    3. Cytochrome-c oxidase in developing rat heart. Enzymic properties and amino-terminal sequences suggest identity of the fetal heart and the adult liver isoform. Schägger H, et al. Eur J Biochem, 1995 May 15. PMID 7601105
    4. Structure of the intact 14-subunit human cytochrome c oxidase. Zong S, et al. Cell Res, 2018 Oct. PMID 30030519, Free PMC Article
    5. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060780, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oxidative phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of respiratory chain complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7A2, mitochondrial
    Names
    cytochrome c oxidase polypeptide 7A2, mitochondrial
    cytochrome c oxidase polypeptide VIIa-liver/heart
    cytochrome c oxidase subunit VIIa 3
    cytochrome c oxidase subunit VIIa polypeptide 2
    cytochrome c oxidase subunit VIIa-L
    cytochrome c oxidase subunit VIIa-liver/heart
    cytochrome c oxidase, subunit 7a 3
    cytochrome c oxidase, subunit VIIa 2
    NP_071948.1
    XP_063121086.1
    XP_063121087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022503.2 → NP_071948.1  cytochrome c oxidase subunit 7A2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_071948.1

      Status: VALIDATED

      Source sequence(s)
      AW521400, BG668415
      UniProtKB/Swiss-Prot
      P35171
      UniProtKB/TrEMBL
      A0A8L2QTB7, B2RYS0
      Related
      ENSRNOP00000098381.1, ENSRNOT00000120756.2
      Conserved Domains (1) summary
      cd00928
      Location:24 → 78
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      89597051..89611032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265017.1 → XP_063121087.1  cytochrome c oxidase subunit 7A2, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      P35171
      UniProtKB/TrEMBL
      A0A8L2QTB7, B2RYS0

    2. XM_063265016.1 → XP_063121086.1  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35171.1 GenPept UniProtKB/Swiss-Prot:P35171

    Gene LinkOut

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