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    ROPN1B rhophilin associated tail protein 1B [ Homo sapiens (human) ]

    Gene ID: 152015, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ROPN1Bprovided by HGNC
    Official Full Name
    rhophilin associated tail protein 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:31927
    See related
    Ensembl:ENSG00000114547 AllianceGenome:HGNC:31927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables protein heterodimerization activity. Predicted to be involved in several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Located in cytoplasm and motile cilium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 113.4) See more
    Orthologs
    all
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    Genomic context

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    See ROPN1B in Genome Data Viewer
    Location:
    3q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (125969178..125983454)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (128701549..128715814)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125688021..125702297)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:125635188-125635778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125650034-125650534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125650535-125651035 Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125655344-125655844 Neighboring gene ALG1 like 1, pseudogene Neighboring gene FBRSL1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:125736296-125736478 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:125740258-125741040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125744116-125744616 Neighboring gene solute carrier family 41 member 3 Neighboring gene uncharacterized LOC124909425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125777675-125778174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14673 Neighboring gene ALDH1L1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125822083-125822904 Neighboring gene aldehyde dehydrogenase 1 family member L1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. Fujita A, et al. J Cell Sci, 2000 Jan. PMID 10591629
    2. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. Carr DW, et al. J Biol Chem, 2001 May 18. PMID 11278869
    3. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in acrosome reaction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in flagellated sperm motility TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ropporin-1B
    Names
    AKAP-binding sperm protein ropporin
    rhophilin-associated protein 1B
    ropporin, rhophilin associated protein 1B
    testis tissue sperm-binding protein Li 83P

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012337.3 → NP_001012337.1  ropporin-1B

      See identical proteins and their annotated locations for NP_001012337.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF231410, HY006578
      Consensus CDS
      CCDS33841.1
      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Related
      ENSP00000251776.4, ENST00000251776.8
      Conserved Domains (1) summary
      cl02594
      Location:12 → 44
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    2. NM_001308313.2 → NP_001295242.1  ropporin-1B

      See identical proteins and their annotated locations for NP_001295242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC141849, DC397187
      Consensus CDS
      CCDS33841.1
      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Related
      ENSP00000426271.1, ENST00000514116.6
      Conserved Domains (1) summary
      cl02594
      Location:12 → 44
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      125969178..125983454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713513.4 → XP_006713576.1  ropporin-1B isoform X1

      See identical proteins and their annotated locations for XP_006713576.1

      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6
      Conserved Domains (1) summary
      cl02594
      Location:12 → 44
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    2. XM_005247138.4 → XP_005247195.1  ropporin-1B isoform X2

      See identical proteins and their annotated locations for XP_005247195.1

      UniProtKB/Swiss-Prot
      Q9BZX4
      Related
      ENSP00000421662.1, ENST00000505382.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      128701549..128715814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345358.1 → XP_054201333.1  ropporin-1B isoform X1

      UniProtKB/Swiss-Prot
      D3DNA6, Q96BM7, Q9BZX4
      UniProtKB/TrEMBL
      A0A140VKG6

    2. XM_054345359.1 → XP_054201334.1  ropporin-1B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZX4.1 GenPept UniProtKB/Swiss-Prot:Q9BZX4

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