Nat8f3 N-acetyltransferase 8 (GCN5-related) family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nat8f3provided by MGI
Official Full Name: N-acetyltransferase 8 (GCN5-related) family member 3provided by MGI
Primary source: MGI:MGI:2136449
See related: Ensembl:ENSMUSG00000051262 AllianceGenome:MGI:2136449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cml3; 4833414A14Rik; 4930583K21Rik
Summary: Enables histone H4 acetyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within axis elongation and negative regulation of cell adhesion. Located in nuclear membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 106.4) and bladder adult (RPKM 4.7) See more
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Genomic context

Location:: 6 C3; 6 37.48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85737613..85742726, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85760631..85765767, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables cysteine-S-conjugate N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axis elongation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in gastrulation with mouth forming second	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISO Inferred from Sequence Orthology more info
NOT located_in extracellular space	ISA Inferred from Sequence Alignment more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetyltransferase family 8 member 3

Names: N-acetyltransferase CML3; camello-like 3; camello-like protein 3; probable N-acetyltransferase CML3

NP_001032931.1

EC 2.3.1.48

XP_017177330.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037842.3 → NP_001032931.1 N-acetyltransferase family 8 member 3

See identical proteins and their annotated locations for NP_001032931.1

Status: VALIDATED

Source sequence(s)

AC162313, AK046314

Consensus CDS

CCDS20299.1

UniProtKB/TrEMBL

A0A0R4J157

Related

ENSMUSP00000093431.5, ENSMUST00000050780.8

Conserved Domains (1) summary

pfam13508
Location:106 → 195

Acetyltransf_7; Acetyltransferase (GNAT) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

85737613..85742726 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321841.2 → XP_017177330.1 N-acetyltransferase family 8 member 3 isoform X1

UniProtKB/TrEMBL

A0A0R4J157

Related

ENSMUSP00000131413.2, ENSMUST00000168531.2

Conserved Domains (1) summary

pfam13508
Location:106 → 195

Acetyltransf_7; Acetyltransferase (GNAT) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_053097.2: Suppressed sequence

Description

NM_053097.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.