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    SPAG11B sperm associated antigen 11B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 641436, updated on 5-Mar-2024

    Summary

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    Gene symbol
    SPAG11B
    Gene description
    sperm associated antigen 11B
    Locus tag
    EGK_18667
    See related
    Ensembl:ENSMMUG00000007467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    EP2; EP2L; SPAG11
    Summary
    This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located within a beta-defensin gene cluster. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Two different N-terminal and seven different C-terminal protein sequences are encoded by these transcript variants. Additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
    Orthologs
    human all
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    Genomic context

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    See SPAG11B in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (7940406..7953715, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (7409335..7425382, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene beta-defensin 4A-like Neighboring gene beta-defensin 103 Neighboring gene beta-defensin 104A Neighboring gene beta-defensin 106A Neighboring gene putative zinc finger protein 705G Neighboring gene beta-defensin 107A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EP2 splicing variants in rhesus monkey (Macaca mulatta) epididymis. Fröhlich O, et al. Biol Reprod, 2003 Jul. PMID 12606416
    2. Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). Avellar MC, et al. Biol Reprod, 2004 Nov. PMID 15229135
    3. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sperm-associated antigen 11B
    Names
    epididymal protein 2
    sperm associated antigen 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037282.2 → NP_001032359.1  sperm-associated antigen 11B isoform L preproprotein

      See identical proteins and their annotated locations for NP_001032359.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (L) represents the longest transcript and encodes the longest isoform (L).
      Source sequence(s)
      AF466351, AY528238
      UniProtKB/TrEMBL
      A0A5F7Z9C3, G7N0G3, Q699S8, Q8SQD0
      Related
      ENSMMUP00000061767.1, ENSMMUT00000095174.1
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    2. NM_001110255.1 → NP_001103725.1  sperm-associated antigen 11B isoform B precursor

      See identical proteins and their annotated locations for NP_001103725.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) has an alternate 5' UTR compared to variant L. The N-terminus of the encoded isoform (B) is identical to that of isoform E, but the remainder of the protein is identical to isoform P.
      Source sequence(s)
      AF466346, AY528233
      UniProtKB/TrEMBL
      Q8SQD5

    3. NM_001110256.1 → NP_001103726.1  sperm-associated antigen 11B isoform C preproprotein

      See identical proteins and their annotated locations for NP_001103726.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) has an alternate 3' UTR, compared to variant L. The resulting isoform (C) has an N-terminus identical to isoform L but a unique C-terminus.
      Source sequence(s)
      AF466347, AY528234
      UniProtKB/TrEMBL
      Q699T2, Q8SQD4
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    4. NM_001110257.1 → NP_001103727.1  sperm-associated antigen 11B isoform E precursor

      See identical proteins and their annotated locations for NP_001103727.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) has an alternate 5' UTR and lacks one internal exon, compared to variant L. The N-terminus of the encoded isoform (E) is identical to isoform B, and its C-terminus is identical to isoform Q.
      Source sequence(s)
      AF466348, AY528235
      UniProtKB/TrEMBL
      Q8SQD3
      Conserved Domains (1) summary
      pfam00711
      Location:27 → 60
      Defensin_beta; Beta defensin

    5. NM_001110258.1 → NP_001103728.1  sperm-associated antigen 11B isoform J preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (J) lacks multiple internal exons, compared to variant L. The resulting isoform (J) has an N-terminus identical to isoform L but a unique C-terminus.
      Source sequence(s)
      AF466349, AY528236
      UniProtKB/TrEMBL
      Q8SQD2
      Related
      ENSMMUP00000068168.1, ENSMMUT00000085749.1
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    6. NM_001110259.1 → NP_001103729.1  sperm-associated antigen 11B isoform K preproprotein

      See identical proteins and their annotated locations for NP_001103729.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (K) lacks multiple in-frame internal exons, compared to variant L. The resulting isoform (K) is shorter than isoform L but is identical to isoform L at the N- and C-termini.
      Source sequence(s)
      AF466350, AY528237
      UniProtKB/TrEMBL
      A0A5F7ZGZ3, Q8SQD1
      Related
      ENSMMUP00000063895.1, ENSMMUT00000107337.1
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    7. NM_001110260.1 → NP_001103730.1  sperm-associated antigen 11B isoform M preproprotein

      See identical proteins and their annotated locations for NP_001103730.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (M) lacks an internal in-frame exon, compared to variant L. The resulting isoform (M) is shorter than isoform L but is identical to isoform L at the N- and C-termini.
      Source sequence(s)
      AF466352, AY528239
      UniProtKB/TrEMBL
      A0A5F8ATX9, Q8SQC9
      Related
      ENSMMUP00000080563.1, ENSMMUT00000097615.1
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    8. NM_001110261.1 → NP_001103731.1  sperm-associated antigen 11B isoform N preproprotein

      See identical proteins and their annotated locations for NP_001103731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (N) lacks multiple internal exons and has an additional frame-shifting exon, compared to variant L. The resulting isoform (N) is identical to isoform L at the N-terminus but has a unique C-terminus.
      Source sequence(s)
      AF466353, AY528239
      UniProtKB/TrEMBL
      Q699S7, Q8SQC8
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    9. NM_001110262.1 → NP_001103732.1  sperm-associated antigen 11B isoform O preproprotein

      See identical proteins and their annotated locations for NP_001103732.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (O) has multiple differences among the internal exons, compared to variant L. The resulting isoform (O) is identical to isoform L at the N-terminus but has a unique C-terminus.
      Source sequence(s)
      AF466354, AY528239
      UniProtKB/TrEMBL
      Q699T2, Q8SQC7
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    10. NM_001110263.1 → NP_001103733.1  sperm-associated antigen 11B isoform P preproprotein

      See identical proteins and their annotated locations for NP_001103733.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (P) has multiple differences among the internal exons, compared to variant L. The resulting isoform (P) is identical to isoform L at the N-terminus but its C-terminus is identical to isoform B.
      Source sequence(s)
      AF466355, AY528239
      UniProtKB/TrEMBL
      F6SVZ7, Q8SQC6
      Conserved Domains (1) summary
      pfam05324
      Location:8 → 74
      Sperm_Ag_HE2; Sperm antigen HE2

    11. NM_001110264.1 → NP_001103734.1  sperm-associated antigen 11B isoform Q precursor

      See identical proteins and their annotated locations for NP_001103734.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Q) lacks multiple in-frame internal exons, compared to variant L. The resulting isoform (Q) is identical to isoform L at the N-terminus but its C-terminus is identical to isoform E.
      Source sequence(s)
      AF466356, AY528239
      UniProtKB/TrEMBL
      Q8SQC5
      Related
      ENSMMUP00000077418.1, ENSMMUT00000081629.1
      Conserved Domains (2) summary
      pfam00711
      Location:29 → 62
      Defensin_beta; Beta defensin
      pfam05324
      Location:8 → 21
      Sperm_Ag_HE2; Sperm antigen HE2

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      7940406..7953715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028852101.1 → XP_028707934.1  sperm-associated antigen 11B isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZHF7
      Related
      ENSMMUP00000064069.1, ENSMMUT00000095605.1
      Conserved Domains (1) summary
      pfam05324
      Location:52 → 118
      Sperm_Ag_HE2; Sperm antigen HE2
    Nucleotide Protein
    Heading Accession and Version

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