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    Tprg1l tumor protein p63 regulated 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tprg1lprovided by RGD
    Official Full Name
    tumor protein p63 regulated 1-likeprovided by RGD
    Primary source
    RGD:1590079
    See related
    EnsemblRapid:ENSRNOG00000046227 AllianceGenome:RGD:1590079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mover
    Summary
    Predicted to enable calmodulin binding activity and identical protein binding activity. Involved in presynaptic modulation of chemical synaptic transmission; regulation of glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in calyx of Held and glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human TPRG1L (tumor protein p63 regulated 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 309.2), Kidney (RPKM 306.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tprg1l in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170004577..170007784, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (164722151..164725358, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (171456299..171459488, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551562 Neighboring gene tumor protein p73 Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene multiple EGF-like-domains 6 Neighboring gene Rho guanine nucleotide exchange factor 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover. Körber C, et al. Neuron, 2015 Aug 5. PMID 26212709
    2. Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. Kremer T, et al. FEBS Lett, 2007 Oct 2. PMID 17869247
    3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mover expression in certain subsets of synapses negatively regulates synaptic release probability in the calyx of Held.
      Title: Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover.
    2. mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals
      Title: Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle docking ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in calyx of Held IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor protein p63-regulated gene 1-like protein
    Names
    mossy-fiber terminal-associated vertebrate-specific presynaptic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110318.2 → NP_001103788.1  tumor protein p63-regulated gene 1-like protein isoform 1

      See identical proteins and their annotated locations for NP_001103788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC160865, EU220430
      UniProtKB/Swiss-Prot
      A8WCF8
      UniProtKB/TrEMBL
      A0A8L2QW99
      Related
      ENSRNOP00000064778.2, ENSRNOT00000075423.4
      Conserved Domains (1) summary
      pfam12456
      Location:61 → 162
      hSac2; Inositol phosphatase

    2. NM_001271085.1 → NP_001258014.1  tumor protein p63-regulated gene 1-like protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon compared to variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC105914, EU220430
      UniProtKB/TrEMBL
      A0A8I5ZPI8
      Conserved Domains (1) summary
      pfam12456
      Location:61 → 151
      hSac2; Inositol phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      170004577..170007784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8WCF8.1 GenPept UniProtKB/Swiss-Prot:A8WCF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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