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    Gprc5d G protein-coupled receptor, class C, group 5, member D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gprc5dprovided by RGD
    Official Full Name
    G protein-coupled receptor, class C, group 5, member Dprovided by RGD
    Primary source
    RGD:1563887
    See related
    EnsemblRapid:ENSRNOG00000008439 AllianceGenome:RGD:1563887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563887
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in extracellular exosome; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human GPRC5D (G protein-coupled receptor class C group 5 member D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 4.3), Spleen (RPKM 1.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gprc5d in Genome Data Viewer
    Location:
    4q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169674874..169686965, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167943523..167955616, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168872897..168884925, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 47 Neighboring gene G protein-coupled receptor, class C, group 5, member A Neighboring gene ribosomal protein S17, pseudogene 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene heme binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Bräuner-Osborne H, et al. Biochim Biophys Acta, 2001 Apr 16. PMID 11311935
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor family C group 5 member D
    Names
    G protein-coupled receptor, family C, group 5, member D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109254.1 → NP_001102724.1  G-protein coupled receptor family C group 5 member D

      See identical proteins and their annotated locations for NP_001102724.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6IMF4, D4A7N4
      Related
      ENSRNOP00000011141.4, ENSRNOT00000011141.6
      Conserved Domains (1) summary
      pfam00003
      Location:61 → 264
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169674874..169686965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286578.1 → XP_063142648.1  G-protein coupled receptor family C group 5 member D isoform X1

      UniProtKB/TrEMBL
      A6IMF4, D4A7N4

    2. XM_039108223.2 → XP_038964151.1  G-protein coupled receptor family C group 5 member D isoform X2

      UniProtKB/TrEMBL
      A6IMF5
      Related
      ENSRNOP00000103192.1, ENSRNOT00000154257.1
      Conserved Domains (2) summary
      cd14964
      Location:21 → 46
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21 → 267
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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