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    Nme4 NME/NM23 nucleoside diphosphate kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685679, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nme4provided by RGD
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 4provided by RGD
    Primary source
    RGD:1591334
    See related
    EnsemblRapid:ENSRNOG00000075475 AllianceGenome:RGD:1591334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTPase binding activity. Predicted to be involved in lipid transport. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of ribonucleoprotein complex. Orthologous to human NME4 (NME/NM23 nucleoside diphosphate kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 115.1), Heart (RPKM 69.8) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nme4 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15619106..15622961, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15114624..15118479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15461567..15465422, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3, pseudogene 2 Neighboring gene 2,4-dienoyl-CoA reductase 2 Neighboring gene 60S ribosomal protein L34-like Neighboring gene post-GPI attachment to proteins 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cardiolipin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nucleoside diphosphate kinase, mitochondrial
    Names
    expressed in non-metastatic cells 4, protein
    non-metastatic cells 4, protein expressed in
    nucleoside diphosphate kinase 4
    NP_001102948.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109478.1NP_001102948.1  nucleoside diphosphate kinase, mitochondrial

      See identical proteins and their annotated locations for NP_001102948.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HD87, D3ZMT9
      Related
      ENSRNOP00000027593.5, ENSRNOT00000027593.8
      Conserved Domains (1) summary
      cd04413
      Location:36165
      NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15619106..15622961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)