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    Olfml2b olfactomedin-like 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304960, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Olfml2bprovided by RGD
    Official Full Name
    olfactomedin-like 2Bprovided by RGD
    Primary source
    RGD:1309257
    See related
    EnsemblRapid:ENSRNOG00000003018 AllianceGenome:RGD:1309257
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable extracellular matrix binding activity and identical protein binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human OLFML2B (olfactomedin like 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 96.5), Muscle (RPKM 95.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Olfml2b in Genome Data Viewer
    Location:
    13q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (85402151..85439342)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (82869414..82906607)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (88995301..89032487)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 1 adaptor protein Neighboring gene uncharacterized LOC120096313 Neighboring gene uncharacterized LOC102550090 Neighboring gene activating transcription factor 6 Neighboring gene U6 spliceosomal RNA Neighboring gene 40S ribosomal protein S27-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of photomedins: novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity. Furutani Y, et al. Biochem J, 2005 Aug 1. PMID 15836428, Free PMC Article
    2. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    3. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactomedin-like protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107195.1 → NP_001100665.1  olfactomedin-like protein 2B precursor

      See identical proteins and their annotated locations for NP_001100665.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      A6IDP9
      Conserved Domains (2) summary
      pfam02191
      Location:494 → 742
      OLF; Olfactomedin-like domain
      pfam05377
      Location:176 → 202
      FlaC_arch; Flagella accessory protein C (FlaC)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      85402151..85439342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250219.4 → XP_006250281.1  olfactomedin-like protein 2B isoform X1

      UniProtKB/TrEMBL
      D4A0J7
      Related
      ENSRNOP00000004117.5, ENSRNOT00000004117.7
      Conserved Domains (2) summary
      pfam02191
      Location:496 → 744
      OLF; Olfactomedin-like domain
      pfam05377
      Location:176 → 202
      FlaC_arch; Flagella accessory protein C (FlaC)
    Nucleotide Protein Strain
    Heading Accession and Version

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