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    Hddc3 HD domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hddc3provided by RGD
    Official Full Name
    HD domain containing 3provided by RGD
    Primary source
    RGD:1311839
    See related
    EnsemblRapid:ENSRNOG00000012236 AllianceGenome:RGD:1311839
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311839
    Summary
    Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Orthologous to human HDDC3 (HD domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 168.2), Kidney (RPKM 134.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hddc3 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143708703..143711010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134299469..134301757)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142136428..142138737)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene shisa like 3 Neighboring gene ribosomal protein L35A like 7 Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene FES proto-oncogene, tyrosine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
    Names
    HD domain-containing protein 3
    NP_001100998.1
    XP_006229493.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107528.1 → NP_001100998.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

      See identical proteins and their annotated locations for NP_001100998.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A6JCA5, D4A500
      Conserved Domains (1) summary
      COG0317
      Location:4 → 130
      SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143708703..143711010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229431.3 → XP_006229493.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQC5
      Related
      ENSRNOP00000016445.5, ENSRNOT00000016445.7
      Conserved Domains (2) summary
      COG0317
      Location:4 → 95
      SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
      cl21469
      Location:3 → 103
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    Nucleotide Protein Strain
    Heading Accession and Version

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