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    Tmem127 transmembrane protein 127 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311405, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tmem127provided by RGD
    Official Full Name
    transmembrane protein 127provided by RGD
    Primary source
    RGD:1309744
    See related
    EnsemblRapid:ENSRNOG00000088819 AllianceGenome:RGD:1309744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309744
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of TOR signaling and negative regulation of cell population proliferation. Predicted to act upstream of or within endosome organization. Predicted to be located in early endosome and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in pheochromocytoma. Orthologous to human TMEM127 (transmembrane protein 127). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 194.6), Lung (RPKM 167.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tmem127 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134919416..134932210)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114466095..114478894)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119677575..119690371)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein U5 subunit 200 Neighboring gene cytosolic iron-sulfur assembly component 1 Neighboring gene StAR-related lipid transfer domain containing 7 Neighboring gene uncharacterized LOC134486147 Neighboring gene uncharacterized LOC103691883

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC156781

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within endosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100978.1NP_001094448.1  transmembrane protein 127

      See identical proteins and their annotated locations for NP_001094448.1

      Status: PROVISIONAL

      Source sequence(s)
      BC131850
      UniProtKB/TrEMBL
      A0A8I6AS31, A2RRU2, A6HQ09
      Related
      ENSRNOP00000102251.1, ENSRNOT00000150685.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134919416..134932210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104991.2XP_038960919.1  transmembrane protein 127 isoform X1