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    Dcaf13 DDB1 and CUL4 associated factor 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcaf13provided by RGD
    Official Full Name
    DDB1 and CUL4 associated factor 13provided by RGD
    Primary source
    RGD:1308458
    See related
    EnsemblRapid:ENSRNOG00000004301 AllianceGenome:RGD:1308458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gm83; Wdsof1
    Summary
    Predicted to enable nuclear estrogen receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including decidualization; oocyte growth; and spindle assembly involved in female meiosis. Predicted to be located in several cellular components, including centrosome; cytosol; and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex and small-subunit processome. Predicted to be active in nucleolus. Orthologous to human DCAF13 (DDB1 and CUL4 associated factor 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 201.7), Liver (RPKM 185.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcaf13 in Genome Data Viewer
    Location:
    7q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (72045828..72081039)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (70160983..70196142)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (78005232..78040220)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene collagen triple helix repeat containing 1 Neighboring gene solute carrier family 25 member 32 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 35 Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene uncharacterized LOC134479901

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Britschgi A, et al. Nature, 2017 Jan 26. PMID 28068668, Free PMC Article
    2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in decidualization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic programming in the zygotic pronuclei ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oocyte growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly involved in female meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 13
    Names
    WD repeats and SOF domain containing 1
    WD repeats and SOF1 domain containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173558.1 → NP_001167029.1  DDB1- and CUL4-associated factor 13

      Status: VALIDATED

      Source sequence(s)
      BC158730, EV763930
      UniProtKB/TrEMBL
      A6HR70
      Related
      ENSRNOP00000005803.7, ENSRNOT00000005803.8
      Conserved Domains (3) summary
      cd00200
      Location:59 → 353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:70 → 107
      7WD40; WD40 repeat [structural motif]
      pfam04158
      Location:354 → 440
      Sof1; Sof1-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      72045828..72081039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263835.1 → XP_063119905.1  DDB1- and CUL4-associated factor 13 isoform X1

      UniProtKB/TrEMBL
      B0BN91

    2. XM_063263836.1 → XP_063119906.1  DDB1- and CUL4-associated factor 13 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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