TCERG1L transcription elongation regulator 1 like [Homo sapiens (human)] - Gene

Summary

Official Symbol: TCERG1Lprovided by HGNC
Official Full Name: transcription elongation regulator 1 likeprovided by HGNC
Primary source: HGNC:HGNC:23533
See related: Ensembl:ENSG00000176769 MIM:620498; AllianceGenome:HGNC:23533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thyroid (RPKM 8.1), ovary (RPKM 1.2) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (131092391..131311721, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (132027431..132247342, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (132890654..133109984, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TCERG1L is associated with plasma adiponectin, a key modulator of obesity, inflammation, IR and diabetes.
Title: Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Case-control genome-wide association study of attention-deficit/hyperactivity disorder.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-81985 (e-PCR)
- UniSTS:102963

SHGC-147201 (e-PCR)
- UniSTS:175673

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-107424 (e-PCR)
- UniSTS:170362

RH102879 (e-PCR)
- UniSTS:97213

D10S1155 (e-PCR)
- UniSTS:10433

RH76735 (e-PCR)
- UniSTS:86747

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription elongation regulator 1-like protein

Names: 5730476P14Rik

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174937.4 → NP_777597.2 transcription elongation regulator 1-like protein

See identical proteins and their annotated locations for NP_777597.2

Status: VALIDATED

Source sequence(s)

AL390203, BC042951, BC101535, BM689725

Consensus CDS

CCDS7662.2

UniProtKB/Swiss-Prot

Q5VWI1, Q5VWI2, Q86XM8

Related

ENSP00000357631.4, ENST00000368642.4

Conserved Domains (2) summary

pfam00397
Location:343 → 370

WW; WW domain

pfam01846
Location:452 → 500

FF; FF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

131092391..131311721 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047424966.1 → XP_047280922.1 transcription elongation regulator 1-like protein isoform X1
XM_047424967.1 → XP_047280923.1 transcription elongation regulator 1-like protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

132027431..132247342 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054365420.1 → XP_054221395.1 transcription elongation regulator 1-like protein isoform X1
XM_054365421.1 → XP_054221396.1 transcription elongation regulator 1-like protein isoform X2