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    C4orf33 chromosome 4 open reading frame 33 [ Homo sapiens (human) ]

    Gene ID: 132321, updated on 3-Dec-2024

    Summary

    Official Symbol
    C4orf33provided by HGNC
    Official Full Name
    chromosome 4 open reading frame 33provided by HGNC
    Primary source
    HGNC:HGNC:27025
    See related
    Ensembl:ENSG00000151470 AllianceGenome:HGNC:27025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in colon (RPKM 3.9), duodenum (RPKM 3.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See C4orf33 in Genome Data Viewer
    Location:
    4q28.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (129093712..129116637)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (132397882..132420798)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (130014867..130037792)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr4:129697052-129697573 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129723780-129724699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129734111-129734692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129734693-129735274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21898 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:129752609-129753288 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:129753289-129753968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129756920-129757462 Neighboring gene jade family PHD finger 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21899 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21902 Neighboring gene CDRT15 pseudogene 11 Neighboring gene zinc finger SWIM-type containing 5 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of chromosome 4 open reading frame 33 (C4orf33) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099783.2NP_001093253.1  UPF0462 protein C4orf33

      See identical proteins and their annotated locations for NP_001093253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093826, BC032582, BE566349, BQ549846, BU783470, CN483524
      Consensus CDS
      CCDS3741.1
      UniProtKB/Swiss-Prot
      D3DNY2, Q6PJF3, Q8N1A6, Q8NBC5
      UniProtKB/TrEMBL
      D6RIT3
      Related
      ENSP00000401090.1, ENST00000425929.6
      Conserved Domains (1) summary
      cl14783
      Location:42171
      DOMON_like; Domon-like ligand-binding domains
    2. NM_173487.3NP_775758.2  UPF0462 protein C4orf33

      See identical proteins and their annotated locations for NP_775758.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093826, BC032582, BP871612, BQ549846, BU783470
      Consensus CDS
      CCDS3741.1
      UniProtKB/Swiss-Prot
      D3DNY2, Q6PJF3, Q8N1A6, Q8NBC5
      UniProtKB/TrEMBL
      D6RIT3
      Related
      ENSP00000281146.4, ENST00000281146.9
      Conserved Domains (1) summary
      cl14783
      Location:42171
      DOMON_like; Domon-like ligand-binding domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      129093712..129116637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007724.2XP_016863213.1  UPF0462 protein C4orf33 isoform X1

      UniProtKB/TrEMBL
      D6RIT3
      Related
      ENSP00000427406.1, ENST00000502887.5
      Conserved Domains (1) summary
      cl14783
      Location:4294
      DOMON_like; Domon-like ligand-binding domains
    2. XM_047449598.1XP_047305554.1  UPF0462 protein C4orf33 isoform X1

      UniProtKB/TrEMBL
      D6RIT3
    3. XM_047449599.1XP_047305555.1  UPF0462 protein C4orf33 isoform X2

      UniProtKB/TrEMBL
      D6RIT3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      132397882..132420798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348895.1XP_054204870.1  UPF0462 protein C4orf33 isoform X1

      UniProtKB/TrEMBL
      D6RIT3
    2. XM_054348893.1XP_054204868.1  UPF0462 protein C4orf33 isoform X1

      UniProtKB/TrEMBL
      D6RIT3
    3. XM_054348894.1XP_054204869.1  UPF0462 protein C4orf33 isoform X2

      UniProtKB/TrEMBL
      D6RIT3
    4. XM_054348896.1XP_054204871.1  UPF0462 protein C4orf33 isoform X3

      UniProtKB/TrEMBL
      D6RD26