BGN biglycan [Homo sapiens (human)] - Gene

Summary

Official Symbol: BGNprovided by HGNC
Official Full Name: biglycanprovided by HGNC
Primary source: HGNC:HGNC:1044
See related: Ensembl:ENSG00000182492 MIM:301870; AllianceGenome:HGNC:1044
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A
Summary: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Expression: Broad expression in gall bladder (RPKM 206.5), spleen (RPKM 159.3) and 20 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: Xq28

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (153494980..153509546)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (151768553..151783109)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (152760438..152775004)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of gastric cancer cells through modulating miR-429/BGN axis.
Title: Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of gastric cancer cells through modulating miR-429/BGN axis.
Stroma biglycan expression can be a prognostic factor in prostate cancers.
Title: Stroma biglycan expression can be a prognostic factor in prostate cancers.
Biglycan promotes hepatic fibrosis through activating heat shock protein 47.
Title: Biglycan promotes hepatic fibrosis through activating heat shock protein 47.
Identification of BGN and THBS2 as metastasis-specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis.
Title: Identification of BGN and THBS2 as metastasis-specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis.
Expression and prognostic analysis of BGN in head and neck squamous cell carcinoma.
Title: Expression and prognostic analysis of BGN in head and neck squamous cell carcinoma.
Identification of Differentially Expressed Genes Reveals BGN Predicting Overall Survival and Tumor Immune Infiltration of Gastric Cancer.
Title: Identification of Differentially Expressed Genes Reveals BGN Predicting Overall Survival and Tumor Immune Infiltration of Gastric Cancer.
Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study.
Title: Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study.
Biglycan: an emerging small leucine-rich proteoglycan (SLRP) marker and its clinicopathological significance.
Title: Biglycan: an emerging small leucine-rich proteoglycan (SLRP) marker and its clinicopathological significance.
Identification of a novel miR-21-3p/TGF-beta signaling-driven immune escape via the MHC class I/biglycan axis in tumor cells.
Title: Identification of a novel miR-21-3p/TGF-β signaling-driven immune escape via the MHC class I/biglycan axis in tumor cells.
Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.
Title: Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.

Submit: New GeneRIF Correction See all GeneRIFs (101)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Meester-Loeys syndrome MedGen: C4310811 OMIM: 300989 GeneReviews: Heritable Thoracic Aortic Disease Overview	Compare labs
X-linked spondyloepimetaphyseal dysplasia MedGen: C1848097 OMIM: 300106 GeneReviews: Not available	Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH75559 (e-PCR)
- UniSTS:90381

G28556 (e-PCR)
- UniSTS:48413

DXS9901 (e-PCR)
- UniSTS:43317

RH91107 (e-PCR)
- UniSTS:92481

STS-M65154 (e-PCR)
- UniSTS:57447

G62027 (e-PCR)
- UniSTS:139113

GDB:192507 (e-PCR)
- UniSTS:99514

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	NAS Non-traceable Author Statement more info	PubMed
enables extracellular matrix structural constituent conferring compression resistance	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables glycosaminoglycan binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in articular cartilage development	IEA Inferred from Electronic Annotation more info
involved_in bone development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal lumen	TAS Traceable Author Statement more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	IDA Inferred from Direct Assay more info

General protein information

Go to the top of the page Help

Preferred Names: biglycan

Names: bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; small leucine-rich protein 1A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015961.1 RefSeqGene

Range

5028..19594

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001711.6 → NP_001702.1 biglycan preproprotein

See identical proteins and their annotated locations for NP_001702.1

Status: REVIEWED

Source sequence(s)

AI538325, AK297966, BC002416, BQ180984, DC299956

Consensus CDS

CCDS14721.1

UniProtKB/Swiss-Prot

D3DWU3, P13247, P21810

UniProtKB/TrEMBL

A8K7E0, Q53FI4

Related

ENSP00000327336.4, ENST00000331595.9

Conserved Domains (4) summary

sd00031
Location:302 → 315

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:71 → 91

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:277 → 323

LRR_8; Leucine rich repeat

cl26018
Location:64 → 297

NEL; C-terminal novel E3 ligase, LRR-interacting

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

153494980..153509546

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017029724.3 → XP_016885213.1 biglycan isoform X1

UniProtKB/Swiss-Prot

D3DWU3, P13247, P21810

UniProtKB/TrEMBL

A8K7E0, Q53FI4

Conserved Domains (4) summary

sd00031
Location:302 → 315

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:71 → 91

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:277 → 323

LRR_8; Leucine rich repeat

cl26018
Location:64 → 297

NEL; C-terminal novel E3 ligase, LRR-interacting