SMT2 sterol methyltransferase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SMT2
Official Full Name: sterol methyltransferase 2
Primary source: TAIR:AT1G20330
Locus tag: AT1G20330
See related: Araport:AT1G20330
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: COTYLEDON VASCULAR PATTERN 1; CVP1; F14O10.7; F14O10_7; FRILL1; FRL1; sterol methyltransferase 2
Summary: Encodes a sterol-C24-methyltransferases involved in sterol biosynthesis. Mutants display altered sterol composition, serrated petals and sepals and altered cotyledon vascular patterning as well as ectopic endoreduplication. This suggests that suppression of endoreduplication is important for petal morphogenesis and that normal sterol composition is required for this suppression.
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Genomic context

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See SMT2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (7038527..7040231, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSL8 and SMT2 proteins are required for ploidy consistency of the sexual reproduction system in Arabidopsis.
Title: GLUCAN SYNTHASE-LIKE8 and STEROL METHYLTRANSFERASE2 are required for ploidy consistency of the sexual reproduction system in Arabidopsis.
SMT3 is functionally redundant with SMT2. Mutants deficient in both SMT1 and SMT2 are embryo lethal. Mutation in both SMT2 and SMT3 causes extreme alteration in sterol composition.
Title: The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products.
Down-regulation of the DET2:DWF4:SMT2 genes in transgenic Arabidopsis leads to a selective modification of the campesterol and brassinosteroid profiles.
Title: Simultaneous suppression of three genes related to brassinosteroid (BR) biosynthesis altered campesterol and BR contents, and led to a dwarf phenotype in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101884.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 24-methylenesterol C-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within multidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xylem and phloem pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: sterol methyltransferase 2

NP_173458.1

sterol methyltransferase 2 (SMT2); FUNCTIONS IN: S-adenosylmethionine-dependent methyltransferase activity; INVOLVED IN: xylem and phloem pattern formation, negative regulation of DNA endoreduplication, multidimensional cell growth, sterol biosynthetic process, pattern specification process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Sterol methyltransferase C-terminal (InterPro:IPR013705), Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: sterol methyltransferase 3 (TAIR:AT1G76090.1); Has 13231 Blast hits to 13223 proteins in 2296 species: Archae - 440; Bacteria - 9200; Metazoa - 162; Fungi - 455; Plants - 664; Viruses - 0; Other Eukaryotes - 2310 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

7038527..7040231 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101884.4 → NP_173458.1 sterol methyltransferase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173458.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39227, Q8H155, Q8L7L3, Q8LCB0, Q9LN25

UniProtKB/TrEMBL

A0A178WHI4, A0A5S9V9B7, A0A7G2DUP0

Conserved Domains (2) summary

pfam08498
Location:292 → 354

Sterol_MT_C; Sterol methyltransferase C-terminal

pfam13649
Location:127 → 221

Methyltransf_25; Methyltransferase domain