pparda peroxisome proliferator-activated receptor delta a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppardaprovided by ZNC
Official Full Name: peroxisome proliferator-activated receptor delta aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-212
See related: Ensembl:ENSDARG00000044525 AllianceGenome:ZFIN:ZDB-GENE-990415-212
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pparb; PPAR[b]; wu:fb60c11
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within neural crest cell development and response to activity. Located in chromatin. Is expressed in several structures, including brain; intestine; liver; ovary; and pectoral fin. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (997791..1022435)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (980860..1005537)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

PPAR expression, the activity of its target gene AOX, and peroxisomal biogenesis are developmentally modulated in zebrafish
Title: Expression of peroxisome proliferator-activated receptors in zebrafish (Danio rerio) depending on gender and developmental stage.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

Preferred Names: peroxisome proliferator-activated receptor delta; peroxisome proliferator-activated receptor delta a

Names: FAAR; NR1C2-A; NUC1; PPARbeta-A; nr1c2a; peroxisome proliferator activated receptor beta

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain

XM_068216510.1 → XP_068072611.1 peroxisome proliferator-activated receptor delta

UniProtKB/TrEMBL

A0A8N7T890, F8W3D2
XM_694808.10 → XP_699900.6 peroxisome proliferator-activated receptor delta

See identical proteins and their annotated locations for XP_699900.6

UniProtKB/TrEMBL

A0A8N7T890, F8W3D2

Related

ENSDARP00000124414.1, ENSDART00000149743.3

Conserved Domains (2) summary

cd06932
Location:228 → 495

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:128 → 211

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers