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    Zfp786 zinc finger protein 786 [ Mus musculus (house mouse) ]

    Gene ID: 330301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp786provided by MGI
    Official Full Name
    zinc finger protein 786provided by MGI
    Primary source
    MGI:MGI:3026883
    See related
    Ensembl:ENSMUSG00000051499 AllianceGenome:MGI:3026883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf786; A730012O14Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus. Orthologous to human ZNF786 (zinc finger protein 786). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 1.8), CNS E18 (RPKM 1.7) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp786 in Genome Data Viewer
    Location:
    6 B2.3; 6 22.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47792470..47817061, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47815536..47836197, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E438 Neighboring gene RNA, Y1 small cytoplasmic, Ro-associated Neighboring gene protein disulfide isomerase associated 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:47763598-47763839 Neighboring gene microRNA 704 Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_15785 Neighboring gene zinc finger protein 398 Neighboring gene zinc finger protein 282 Neighboring gene predicted gene, 52899 Neighboring gene Zinc finger protein 212

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 786

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177882.4 → NP_808550.1  zinc finger protein 786

      See identical proteins and their annotated locations for NP_808550.1

      Status: PROVISIONAL

      Source sequence(s)
      AC166252
      Consensus CDS
      CCDS20098.1
      UniProtKB/Swiss-Prot
      Q8BV42
      UniProtKB/TrEMBL
      B2RSK4
      Related
      ENSMUSP00000057495.6, ENSMUST00000058844.6
      Conserved Domains (5) summary
      smart00349
      Location:9 → 67
      KRAB; krueppel associated box
      COG5048
      Location:226 → 717
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:506 → 526
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:9 → 48
      KRAB; KRAB box
      pfam13465
      Location:658 → 680
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47792470..47817061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255477.2 → XP_030111337.1  zinc finger protein 786 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:113 → 171
      KRAB; krueppel associated box
      COG5048
      Location:330 → 821
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:610 → 630
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:346 → 366
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006506289.5 → XP_006506352.1  zinc finger protein 786 isoform X3

      See identical proteins and their annotated locations for XP_006506352.1

      Conserved Domains (4) summary
      COG5048
      Location:189 → 680
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 30
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_030255479.2 → XP_030111339.1  zinc finger protein 786 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:189 → 680
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 30
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. XM_030255478.1 → XP_030111338.1  zinc finger protein 786 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:189 → 680
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 30
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. XM_006506288.3 → XP_006506351.1  zinc finger protein 786 isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:28 → 86
      KRAB; krueppel associated box
      COG5048
      Location:245 → 736
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:525 → 545
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BV42.1 GenPept UniProtKB/Swiss-Prot:Q8BV42

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