znf703 zinc finger protein 703 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: znf703provided by ZNC
Official Full Name: zinc finger protein 703provided by ZNC
Primary source: ZFIN:ZDB-GENE-010717-1
See related: Ensembl:ENSDARG00000035563 AllianceGenome:ZFIN:ZDB-GENE-010717-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nlz; NH11; nlz1; noz1; cb514; fc45d06; fk28e09; wu:fc45d06; wu:fk28e09; zgc:111927
Summary: Enables histone deacetylase binding activity and identical protein binding activity. Acts upstream of or within several processes, including cilium assembly; embryonic camera-type eye morphogenesis; and negative regulation of DNA-templated transcription. Located in nucleus. Part of histone deacetylase complex. Is expressed in several structures, including anterior neural keel; mesoderm; nervous system; optic cup; and tail bud. Orthologous to human ZNF703 (zinc finger protein 703). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (24329983..24333684, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (23826183..23829884, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nlz1 is required for cilia formation in zebrafish embryogenesis.
Title: nlz1 is required for cilia formation in zebrafish embryogenesis.
identify misregulation of pax2 in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 act upstream of the Pax2 pathway in directing proper closure of the optic fissure
Title: Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure.
Nlz1/Znf703 acts as a repressor of transcription
Title: Nlz1/Znf703 acts as a repressor of transcription.
nlz1 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary. nlz2 is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon.
Title: nlz gene family is required for hindbrain patterning in the zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk28e09.y1 (e-PCR)
- UniSTS:200754

fb12c04.y1 (e-PCR)
- UniSTS:190064

fc45d06 (e-PCR)
- UniSTS:189178

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone deacetylase binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brain development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of homotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 703

Names: nocA related zinc finger 1; nocA-like zinc finger protein 1; nocA-related zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131822.1 → NP_571897.1 zinc finger protein 703

See identical proteins and their annotated locations for NP_571897.1

Status: PROVISIONAL

Source sequence(s)

AF222996

UniProtKB/Swiss-Prot

Q90YM7, Q90ZE2

UniProtKB/TrEMBL

B2GT14

Related

ENSDARP00000051552.3, ENSDART00000051553.4

Conserved Domains (2) summary

sd00017
Location:464 → 490

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12402
Location:328 → 374

nlz1; NocA-like zinc-finger protein 1