GBF1 G-box binding factor 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GBF1
Official Full Name: G-box binding factor 1
Primary source: TAIR:AT4G36730
Locus tag: AT4G36730
See related: Araport:AT4G36730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AP22.21; AP22_21; AtGBF1; G-box binding factor 1
Summary: member of a gene family encoding basic leucine zipper proteins (GBFs) which bind the G-box
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Genomic context

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See GBF1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 12

Sequence:: Chromosome: 4; NC_003075.7 (17309612..17312488, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An interplay between bZIP16, bZIP68, and GBF1 regulates nuclear photosynthetic genes during photomorphogenesis in Arabidopsis.
Title: An interplay between bZIP16, bZIP68, and GBF1 regulates nuclear photosynthetic genes during photomorphogenesis in Arabidopsis.
This study reveals that MYC2 and GBF1 colocalize and physically interact in the nucleus. This interaction requires the N-terminal domain of each protein.
Title: Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development.
GBF1 is a transcriptional repressor of the AtCathB3 gene and affects germination kinetics of A. thaliana seeds. As AtCathB3 is also expressed during post-germination in cotyledons, a role for the AtCathB3-like protease in reserve mobilization is inferred.
Title: The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1.
The DNA binding activity of GBF1 is modulated by heterodimeriation with HY5 and HYH.
Title: Genome-wide DNA binding of GBF1 is modulated by its heterodimerizing protein partners, HY5 and HYH.
Genetic interactions of HY1 and GBF1 in seedling photomorphogenesis.
Title: HY1 genetically interacts with GBF1 and regulates the activity of the Z-box containing promoters in light signaling pathways in Arabidopsis thaliana.
the functional interrelations of GBF1 with HY5 and HYH in Arabidopsis seedling development.
Title: Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana.
In Arabidopsis, GBF1-related exchange factors for the ARF GTPases (ARF GEFs) GNOM and GNL2 play essential roles in polar tip growth of root hairs and pollen, respectively.
Title: Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors.
GBF1, a transcription factor of blue light signaling in Arabidopsis, is degraded in the dark by a proteasome-mediated pathway independent of COP1 and SPA1
Title: GBF1, a transcription factor of blue light signaling in Arabidopsis, is degraded in the dark by a proteasome-mediated pathway independent of COP1 and SPA1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_119837.4

Supported by ESTs:

NM_179179.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: G-box binding factor 1

NP_195391.1

G-box binding factor 1 (GBF1); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), G-box binding, MFMR (InterPro:IPR012900), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: basic region/leucine zipper transcription factor 16 (TAIR:AT2G35530.1); Has 3905 Blast hits to 3842 proteins in 356 species: Archae - 8; Bacteria - 123; Metazoa - 1421; Fungi - 442; Plants - 1419; Viruses - 137; Other Eukaryotes - 355 (source: NCBI BLink).

NP_849510.1

G-box binding factor 1 (GBF1); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), G-box binding, MFMR (InterPro:IPR012900), bZIP transcription factor, bZIP-1 (InterPro:IPR011616); BEST Arabidopsis thaliana protein match is: basic region/leucine zipper transcription factor 16 (TAIR:AT2G35530.1); Has 3891 Blast hits to 3827 proteins in 347 species: Archae - 8; Bacteria - 109; Metazoa - 1441; Fungi - 440; Plants - 1415; Viruses - 137; Other Eukaryotes - 341 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

17309612..17312488 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179179.3 → NP_849510.1 G-box binding factor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849510.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XZX0, A0A7G2F6E6

Conserved Domains (4) summary

smart00338
Location:218 → 282

BRLZ; basic region leucin zipper

cd14702
Location:223 → 274

bZIP_plant_GBF1; coiled coil [structural motif]

pfam07777
Location:1 → 94

MFMR; G-box binding protein MFMR

pfam16596
Location:129 → 209

MFMR_assoc; Disordered region downstream of MFMR
NM_119837.4 → NP_195391.1 G-box binding factor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195391.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42774, Q940I9, Q944J1, Q96263

UniProtKB/TrEMBL

A0A178V1V9, A0A384KK13, A0A5S9XZX0, Q5K1L6

Conserved Domains (3) summary

smart00338
Location:220 → 284

BRLZ; basic region leucin zipper

cd14702
Location:225 → 276

bZIP_plant_GBF1; coiled coil [structural motif]

pfam07777
Location:1 → 94

MFMR; G-box binding protein MFMR