U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    ATCS Citrate synthase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819042, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATCS
    Official Full Name
    Citrate synthase family protein
    Primary source
    TAIR:AT2G44350
    Locus tag
    AT2G44350
    See related
    Araport:AT2G44350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CITRATE SYNTHASE 4; CSY4; F4I1.16
    Summary
    encodes a mitochrondrion targeted citrate synthase, the first enzyme of the tricarboxylic acid cycle, catalyzing the condensation of acetyl-CoA and oxaloacetate, finally yielding citrate and CoA.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATCS in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    21
    Sequence:
    Chromosome: 2; NC_003071.7 (18316278..18320789)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene VQ motif-containing protein Neighboring gene ecotropic viral integration site protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure and expression of mitochondrial citrate synthases from higher plants. La Cognata U, et al. Plant Cell Physiol, 1996 Oct. PMID 8979399
    2. Over expression of mitochondrial citrate synthase gene improves the growth of carrot cells in Al-phosphate medium. Koyama H, et al. Plant Cell Physiol, 1999 May. PMID 10427772
    3. Redox regulation of Arabidopsis mitochondrial citrate synthase. Schmidtmann E, et al. Mol Plant, 2014 Jan. PMID 24198232
    4. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    5. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Redox regulation of Arabidopsis mitochondrial citrate synthase
      Title: Redox regulation of Arabidopsis mitochondrial citrate synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001337082.1
    NM_001337083.1
    NM_129998.3
    NM_180084.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables citrate (Si)-synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Citrate synthase family protein
    NP_566016.1
    • ATCS; FUNCTIONS IN: citrate (SI)-synthase activity, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, tricarboxylic acid cycle; LOCATED IN: mitochondrion, cell wall, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Citrate synthase-like, large alpha subdomain (InterPro:IPR016142), Citrate synthase, eukaryotic (InterPro:IPR010109), Citrate synthase active site (InterPro:IPR019810), Citrate synthase-like (InterPro:IPR002020), Citrate synthase-like, core (InterPro:IPR016141); BEST Arabidopsis thaliana protein match is: citrate synthase 5 (TAIR:AT3G60100.1); Has 10534 Blast hits to 10528 proteins in 2768 species: Archae - 158; Bacteria - 6911; Metazoa - 258; Fungi - 320; Plants - 178; Viruses - 0; Other Eukaryotes - 2709 (source: NCBI BLink).
    NP_850415.1
    • ATCS; FUNCTIONS IN: citrate (SI)-synthase activity, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, tricarboxylic acid cycle; LOCATED IN: mitochondrion, cell wall, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Citrate synthase-like, large alpha subdomain (InterPro:IPR016142), Citrate synthase, eukaryotic (InterPro:IPR010109), Citrate synthase active site (InterPro:IPR019810), Citrate synthase-like, core (InterPro:IPR016141), Citrate synthase-like (InterPro:IPR002020); BEST Arabidopsis thaliana protein match is: citrate synthase 5 (TAIR:AT3G60100.1); Has 10608 Blast hits to 10602 proteins in 2793 species: Archae - 158; Bacteria - 6984; Metazoa - 258; Fungi - 321; Plants - 178; Viruses - 0; Other Eukaryotes - 2709 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18316278..18320789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180084.2 → NP_850415.1  Citrate synthase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64869, P20115, Q8LE36, Q94EY6
      UniProtKB/TrEMBL
      A0A7G2EHB4
      Conserved Domains (2) summary
      cd06105
      Location:41 → 467
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
      PLN02456
      Location:9 → 474
      PLN02456; citrate synthase

    2. NM_129998.3 → NP_566016.1  Citrate synthase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566016.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VUU3, A0A5S9X6X1, A0A7G2EHB4
      Conserved Domains (1) summary
      cd06105
      Location:40 → 466
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...

    3. NM_001337082.1 → NP_001324514.1  Citrate synthase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64869, P20115, Q8LE36, Q94EY6
      UniProtKB/TrEMBL
      A0A7G2EHB4

    4. NM_001337083.1 → NP_001324515.1  Citrate synthase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VUU3, A0A5S9X6X1, A0A7G2EHB4
      Conserved Domains (1) summary
      cd06105
      Location:40 → 466
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20115.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools