SHD Chaperone protein htpG family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SHD
Official Full Name: Chaperone protein htpG family protein
Primary source: TAIR:AT4G24190
Locus tag: AT4G24190
See related: Araport:AT4G24190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtHsp90-7; AtHsp90.7; HEAT SHOCK PROTEIN 90-7; HEAT SHOCK PROTEIN 90.7; HSP90.7; SHEPHERD; T22A6.20; T22A6_20
Summary: encodes an ortholog of GRP94, an ER-resident HSP90-like protein and is involved in regulation of meristem size and organization. Single and double mutant analyses suggest that SHD may be required for the correct folding and/or complex formation of CLV proteins. Lines carrying recessive mutations in this locus exhibits expanded shoot meristems, disorganized root meristems, and defective pollen tube elongation. Transcript is detected in all tissues examined and is not induced by heat. Endoplasmin supports the protein secretory pathway and has a role in proliferating tissues.
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Genomic context

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See SHD in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 15

Sequence:: Chromosome: 4; NC_003075.7 (12551552..12556058, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Seedlings expressing HSP90.7(Delta22) had enhanced sensitivity to ER stress induced by tunicamycin or high concentration of calcium. Its general chaperone activity in preventing the model protein from heat-induced aggregation was not significantly affected.
Title: A highly charged region in the middle domain of plant endoplasmic reticulum (ER)-localized heat-shock protein 90 is required for resistance to tunicamycin or high calcium-induced ER stresses.
Results show that the induction expression of ABA-responsive genes under salt and drought stress was delayed by constitutive overexpression of cytosolic AtHsp90.2, but was hardly affected by that of organellar AtHsp90.5 and AtHsp90.7.
Title: Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_118552.4

Supported by ESTs:

NM_202877.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of meristem growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of meristem structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in secretory vesicle	HDA more info	PubMed

General protein information

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Preferred Names: Chaperone protein htpG family protein

NP_194150.1

SHEPHERD (SHD); FUNCTIONS IN: unfolded protein binding, ATP binding; INVOLVED IN: in 8 processes; LOCATED IN: in 7 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Molecular chaperone, heat shock protein, endoplasmin (InterPro:IPR015566), ATPase-like, ATP-binding domain (InterPro:IPR003594), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568); BEST Arabidopsis thaliana protein match is: heat shock protein 90.1 (TAIR:AT5G52640.1); Has 10659 Blast hits to 10182 proteins in 2496 species: Archae - 7; Bacteria - 3605; Metazoa - 2791; Fungi - 470; Plants - 491; Viruses - 10; Other Eukaryotes - 3285 (source: NCBI BLink).

NP_974606.1

SHEPHERD (SHD); FUNCTIONS IN: unfolded protein binding, ATP binding; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Molecular chaperone, heat shock protein, endoplasmin (InterPro:IPR015566), ATPase-like, ATP-binding domain (InterPro:IPR003594), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568); BEST Arabidopsis thaliana protein match is: heat shock protein 90.1 (TAIR:AT5G52640.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12551552..12556058 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118552.4 → NP_194150.1 Chaperone protein htpG family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194150.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22972, Q56Y38, Q8VY71, Q9STX5

UniProtKB/TrEMBL

A0A654FS92, Q8RVG8

Conserved Domains (3) summary

PRK05218
Location:74 → 763

PRK05218; heat shock protein 90; Provisional

pfam00183
Location:258 → 775

HSP90; Hsp90 protein

pfam02518
Location:104 → 253

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
NM_202877.1 → NP_974606.1 Chaperone protein htpG family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974606.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FS92, F4JQ55, Q8RVG8

Conserved Domains (3) summary

PRK05218
Location:74 → 763

PRK05218; heat shock protein 90; Provisional

pfam00183
Location:258 → 775

HSP90; Hsp90 protein

pfam02518
Location:104 → 253

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase