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    Muc19 mucin 19 [ Mus musculus (house mouse) ]

    Gene ID: 239611, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Muc19provided by MGI
    Official Full Name
    mucin 19provided by MGI
    Primary source
    MGI:MGI:2676278
    See related
    Ensembl:ENSMUSG00000118670 AllianceGenome:MGI:2676278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sld; MUC-19
    Summary
    Enables hydroxyapatite binding activity. Acts upstream of or within several processes, including exocrine system development; hemopoiesis; and lymphocyte proliferation. Predicted to be located in extracellular region. Is expressed in sublingual gland; sublingual gland epithelium; and submandibular duct. Used to study Sjogren's syndrome. Orthologous to human MUC19 (mucin 19, oligomeric). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 2.4), frontal lobe adult (RPKM 1.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Muc19 in Genome Data Viewer
    Location:
    15 E3; 15 46.14 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (91722531..91832440)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4147 Neighboring gene leucine-rich repeat kinase 2 Neighboring gene STARR-seq mESC enhancer starr_39505 Neighboring gene RAS related protein 1b pseudogene Neighboring gene STARR-seq mESC enhancer starr_39506 Neighboring gene STARR-seq mESC enhancer starr_39507 Neighboring gene submandibular gland protein C Neighboring gene STARR-seq mESC enhancer starr_39508 Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 2 pseudogene Neighboring gene leucine-rich repeat LGI family, member 1 pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000081.7 Chromosome 15 Reference GRCm39 C57BL/6J

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiation. Hayashi Y, et al. Am J Pathol, 1988 Aug. PMID 3400771, Free PMC Article
    2. CD4(+) T-cell-dependent differentiation of CD23(+) follicular B cells contributes to the pulmonary pathology in a primary Sjögren's syndrome mouse model. Sato-Fukuba M, et al. Front Immunol, 2023. PMID 37475871, Free PMC Article
    3. Human Metapneumovirus Induces Mucin 19 Which Contributes to Viral Pathogenesis. McBride K, et al. Pathogens, 2020 Sep 3. PMID 32899224, Free PMC Article
    4. Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjögren's syndrome. Saegusa K, et al. J Immunol, 2000 Aug 15. PMID 10925313
    5. Improvement of lacrimal function by topical application of CyA in murine models of Sjögren's syndrome. Tsubota K, et al. Invest Ophthalmol Vis Sci, 2001 Jan. PMID 11133854

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Muc19 assists in bacterial clearance through formation of heterotypic complexes with salivary constituents that bind S. mutans, thus representing a novel innate immune function for salivary gel-forming mucins.
      Title: Salivary mucin 19 glycoproteins: innate immune functions in Streptococcus mutans-induced caries in mice and evidence for expression in human saliva.
    2. The sld mutation disrupts apomucin transcriptional regulation and/or decreases apomucin mRNA stability in NFS/N-sld mice.
      Title: The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression.
    3. The mutation in intron 53 thus enhances aberrant splicing leading to degradation of aberrant transcripts and decreased Muc19 message stability, consistent with the sld phenotype.
      Title: The sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decay.
    4. tissue distibution of murine muc19 and smgc
      Title: Tissue distibution of murine Muc19/smgc gene products.
    5. Changes in Muc19/Smgc gene expression delineate multiple stages of salivary mucous cell cytodifferentiation and subsequent maturation during embryonic gland development through the first 4 weeks of postnatal life.
      Title: Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.
    6. identification, cloning and expression of mucin 19; expression of this gene is restricted to the mucous cells of various glandular tissues
      Title: Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues.
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    sublingual gland differentiation arrest
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydroxyapatite binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within antibacterial innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation involved in salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chemokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within follicular B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lacrimal gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mucin-19
    Names
    gel-forming secreted mucin-19
    sublingual apomucin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207243.3 → NP_997126.2  mucin-19 precursor

      See identical proteins and their annotated locations for NP_997126.2

      Status: VALIDATED

      Source sequence(s)
      FQ976815
      UniProtKB/Swiss-Prot
      A7UN62, A7UN63, A7UN64, A7UN66, Q6P7U5, Q6PZE0, Q6Y0X6, Q80UR5
      Related
      ENSMUSP00000159433.2, ENSMUST00000239545.1
      Conserved Domains (5) summary
      smart00041
      Location:7437 → 7519
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:7309 → 7364
      VWC; von Willebrand factor (vWF) type C domain
      smart00216
      Location:842 → 1003
      VWD; von Willebrand factor (vWF) type D domain
      pfam01826
      Location:298 → 353
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1044 → 1114
      C8; C8 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      91722531..91832440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PZE0.2 GenPept UniProtKB/Swiss-Prot:Q6PZE0

    Gene LinkOut

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