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    Nfkbil1 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 [ Mus musculus (house mouse) ]

    Gene ID: 18038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nfkbil1provided by MGI
    Official Full Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1provided by MGI
    Primary source
    MGI:MGI:1340031
    See related
    Ensembl:ENSMUSG00000042419 AllianceGenome:MGI:1340031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IKBL; Def-7; ikappaBL
    Summary
    Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction. Is active in nucleus. Is expressed in embryo; eye; and heart. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human NFKBIL1 (NFKB inhibitor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.4), ovary adult (RPKM 20.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfkbil1 in Genome Data Viewer
    Location:
    17 B1; 17 18.6 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35439151..35455457, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35220175..35236481, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35337508-35337695 Neighboring gene tumor necrosis factor Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A Neighboring gene STARR-positive B cell enhancer ABC_E11642 Neighboring gene STARR-positive B cell enhancer ABC_E5601 Neighboring gene STARR-positive B cell enhancer ABC_E7528 Neighboring gene STARR-positive B cell enhancer ABC_E1942 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G2 Neighboring gene STARR-positive B cell enhancer ABC_E10948 Neighboring gene DEAD box helicase 39b Neighboring gene predicted gene, 22589 Neighboring gene microRNA 6975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis and expression of a mouse homolog of human IkappaBL gene. Handel-Fernandez ME, et al. Biochim Biophys Acta, 1999 Feb 16. PMID 10023090
    2. NFKBIL1 confers resistance to experimental autoimmune arthritis through the regulation of dendritic cell functions. Chiba T, et al. Scand J Immunol, 2011 May. PMID 21284685
    3. IκBL, a novel member of the nuclear IκB family, inhibits inflammatory cytokine expression. Chiba T, et al. FEBS Lett, 2011 Nov 16. PMID 22024480
    4. A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. McIntyre RE, et al. G3 (Bethesda), 2016 Aug 9. PMID 27233670, Free PMC Article
    5. Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system. Hotfilder M, et al. Br J Haematol, 1999 Aug. PMID 10460589

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NFKBIL-1 affects the pathogenesis of rheumatoid arthritis at least in part by the regulation of dendritic cell functions.
      Title: NFKBIL1 confers resistance to experimental autoimmune arthritis through the regulation of dendritic cell functions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor-like protein 1
    Names
    I-kappa-B-like protein
    inhibitor of kappa B-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364909.1 → NP_001351838.1  NF-kappa-B inhibitor-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      Q3V006
      Conserved Domains (2) summary
      cd00204
      Location:45 → 115
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    2. NM_010909.5 → NP_035039.1  NF-kappa-B inhibitor-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_035039.1

      Status: VALIDATED

      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28693.1
      UniProtKB/Swiss-Prot
      O88995, Q91X16, Q9R1Y3
      UniProtKB/TrEMBL
      Q3V006
      Related
      ENSMUSP00000035452.7, ENSMUST00000048994.7
      Conserved Domains (4) summary
      cd00204
      Location:69 → 139
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:43 → 110
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:84 → 142
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:65 → 96
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35439151..35455457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88995.1 GenPept UniProtKB/Swiss-Prot:O88995

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