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    Traf3ip2 TRAF3 interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 103213, updated on 9-Dec-2024

    Summary

    Official Symbol
    Traf3ip2provided by MGI
    Official Full Name
    TRAF3 interacting protein 2provided by MGI
    Primary source
    MGI:MGI:2143599
    See related
    Ensembl:ENSMUSG00000019842 AllianceGenome:MGI:2143599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Act1; CIKS
    Summary
    Enables signaling receptor binding activity and ubiquitin protein ligase activity. Involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte differentiation. Acts upstream of or within B cell apoptotic process and humoral immune response. Is active in cytoplasmic vesicle and nucleus. Used to study Sjogren's syndrome; atopic dermatitis; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Act1 (Gene ID:109776) and Traf3ip2 (Gene ID:103213) share the Act1 symbol/alias in common. Act1 is a widely used alternative name for adapter protein CIKS (Traf3ip2), which can be confused with the official symbol for Act1, actin related gene 1 (Act1). [15 Oct 2019]
    Expression
    Broad expression in colon adult (RPKM 15.9), ovary adult (RPKM 14.1) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Traf3ip2 in Genome Data Viewer
    Location:
    10 B1; 10 20.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39488930..39531303)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39612934..39655307)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:39089323-39089624 Neighboring gene Fyn proto-oncogene Neighboring gene STARR-seq mESC enhancer starr_26390 Neighboring gene STARR-seq mESC enhancer starr_26392 Neighboring gene predicted gene 16364 Neighboring gene STARR-seq mESC enhancer starr_26396 Neighboring gene predicted gene, 40627 Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene STARR-seq mESC enhancer starr_26400 Neighboring gene predicted gene 8899 Neighboring gene predicted gene, 53621

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell affinity maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B cell mediated immunity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in CD40 signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in T-helper 17 type immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cytokine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to interleukin-17 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine production involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eosinophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eosinophil mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of T cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in interleukin-17-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-17-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interleukin-17-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-17A-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-17A-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interleukin-17A-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte activation involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymph node development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of defense response to virus by host IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cytokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transitional two stage B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin ligase TRAF3IP2
    Names
    E3 ubiquitin-protein ligase CIKS
    adapter protein CIKS
    connection to IKK and SAPK/JNK
    nuclear factor NF-kappa-B activator 1
    NP_598761.2
    XP_011241407.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134000.3NP_598761.2  E3 ubiquitin ligase TRAF3IP2

      See identical proteins and their annotated locations for NP_598761.2

      Status: VALIDATED

      Source sequence(s)
      AC160403
      Consensus CDS
      CCDS23789.1
      UniProtKB/Swiss-Prot
      Q8BH33, Q8N7N6
      UniProtKB/TrEMBL
      Q8C0E5
      Related
      ENSMUSP00000019987.7, ENSMUST00000019987.7
      Conserved Domains (2) summary
      PRK10263
      Location:217373
      PRK10263; DNA translocase FtsK; Provisional
      pfam08357
      Location:391533
      SEFIR; SEFIR domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      39488930..39531303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243105.2XP_011241407.1  E3 ubiquitin ligase TRAF3IP2 isoform X1

      UniProtKB/TrEMBL
      Q8C0E5
      Conserved Domains (2) summary
      PRK10263
      Location:245401
      PRK10263; DNA translocase FtsK; Provisional
      pfam08357
      Location:419561
      SEFIR; SEFIR domain