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    P2rx6 purinergic receptor P2X 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P2rx6provided by RGD
    Official Full Name
    purinergic receptor P2X 6provided by RGD
    Primary source
    RGD:3243
    See related
    EnsemblRapid:ENSRNOG00000001873 AllianceGenome:RGD:3243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P2x6; P2rxl1; Rnap2x6
    Summary
    Enables extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Located in dendritic spine and neuronal cell body. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic specialization membrane. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 54.0), Lung (RPKM 24.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See P2rx6 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96944167..96956424, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83439922..83450449, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87434929..87445221)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 2 Neighboring gene uncharacterized LOC108352364 Neighboring gene solute carrier family 7, member 4 Neighboring gene leucine rich repeat containing 74B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene THAP domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract. Yu Q, et al. Histochem Cell Biol, 2010 Feb. PMID 19946698
    2. The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Barrera NP, et al. Biophys J, 2007 Jul 15. PMID 17449665, Free PMC Article
    3. Cloning and tissue distribution of a novel P2X receptor from rat brain. Soto F, et al. Biochem Biophys Res Commun, 1996 Jun 14. PMID 8670303
    4. Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. Collo G, et al. J Neurosci, 1996 Apr 15. PMID 8786426, Free PMC Article
    5. P2X receptor trafficking in neurons is subunit specific. Bobanovic LK, et al. J Neurosci, 2002 Jun 15. PMID 12077178, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P2X4 and P2X6 proteins were expressed in a different way during rat small intestine development, showing a higher colocalization coefficient at age P30 in both intestine regions. Those results suggest that purinergic receptors may play a role in intestinal maturation, which is associated with age and intestinal region.
      Title: Differential gene expression patterns and colocalization of ATP-gated P2X6/P2X4 ion channels during rat small intestine ontogeny.
    2. The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp.
      Title: Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.
    3. P2X(4) and P2X(6) purinoreceptors are present in the gut from birth and that they are differentially distributed among regions
      Title: Distribution of the purinegic receptors P2X(4) and P2X(6) during rat gut development.
    4. The P2X6 receptor subunit is widely expressed in neuropils in the whole gray matter except for the dorsal superficial layer of the dorsal horn.
      Title: Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.
    5. Results suggest a direct relationship between purinergic P2X2/6 receptor expression and induction of neuronal differentiation in mitogen-free cultured rat neurospheres.
      Title: Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors.
    6. The P2X(6) receptors are mainly expressed on intrinsic sensory neurons and that ATP, via P2X(6) receptors probably in heteromeric combination with P2X(2) receptors, may be involved in regulating the physiological functions of these neurons.
      Title: Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.
    7. P2X(2) receptors are trimers, whereas the P2X(6) receptor subunits do not form stable oligomers
      Title: Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellularly ATP-gated monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellularly ATP-gated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    P2X purinoceptor 6
    Names
    ATP receptor
    P2X6 receptor
    P2XM
    purinergic receptor P2X, ligand-gated ion channel, 6
    purinergic receptor P2X-like 1 orphan receptor
    purinergic receptor P2X6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012721.2 → NP_036853.2  P2X purinoceptor 6

      See identical proteins and their annotated locations for NP_036853.2

      Status: VALIDATED

      Source sequence(s)
      CO554543, X92070, X97376
      UniProtKB/Swiss-Prot
      P51579, R9PXR5
      UniProtKB/TrEMBL
      A0A8I6ADW0
      Related
      ENSRNOP00000002558.6, ENSRNOT00000002558.8
      Conserved Domains (1) summary
      TIGR00863
      Location:22 → 376
      P2X; cation transporter protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96944167..96956424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270294.1 → XP_063126364.1  P2X purinoceptor 6 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ADW0

    2. XM_063270292.1 → XP_063126362.1  P2X purinoceptor 6 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ADW0, A0A8I6ATC1
      Related
      ENSRNOP00000096439.1, ENSRNOT00000100698.2

    3. XM_039087989.2 → XP_038943917.1  P2X purinoceptor 6 isoform X2

      Conserved Domains (1) summary
      TIGR00863
      Location:46 → 404
      P2X; cation transporter protein

    4. XM_039087988.2 → XP_038943916.1  P2X purinoceptor 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADW0
      Conserved Domains (1) summary
      TIGR00863
      Location:22 → 415
      P2X; cation transporter protein

    5. XM_039087991.2 → XP_038943919.1  P2X purinoceptor 6 isoform X8

      Conserved Domains (1) summary
      cl02993
      Location:1 → 226
      P2X_receptor; ATP P2X receptor

    6. XM_063270291.1 → XP_063126361.1  P2X purinoceptor 6 isoform X4

    7. XM_039087990.2 → XP_038943918.1  P2X purinoceptor 6 isoform X3

      Conserved Domains (1) summary
      cl02993
      Location:22 → 339
      P2X_receptor; ATP P2X receptor

    8. XM_063270293.1 → XP_063126363.1  P2X purinoceptor 6 isoform X6

      Related
      ENSRNOP00000111441.1, ENSRNOT00000150988.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51579.2 GenPept UniProtKB/Swiss-Prot:P51579

    Gene LinkOut

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