Txndc17 thioredoxin domain containing 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Txndc17provided by MGI
Official Full Name: thioredoxin domain containing 17provided by MGI
Primary source: MGI:MGI:1289248
See related: Ensembl:ENSMUSG00000020803 AllianceGenome:MGI:1289248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRP14; Txnl5; D11Ertd672e; 4831443O22Rik
Summary: Predicted to enable peroxidase activity and protein-disulfide reductase (NAD(P)H) activity. Predicted to be involved in tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytosol. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 53.8), large intestine adult (RPKM 37.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 43.92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72098380..72101313)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72207554..72210487)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Title: TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Control of protein function through oxidation and reduction of persulfidated states.
Title: Control of protein function through oxidation and reduction of persulfidated states.
Results suggest that TRP14 regulates osteoclasts differentiation and bone resorption through its catalytic activity and that enhancing TRP14 may present a new strategy for preventing bone resorption diseases.
Title: TRP14 inhibits osteoclast differentiation via its catalytic activity.
In this review, we will summarize the cardiac effects of thioredoxin and the mechanisms by which thioredoxin mediates inhibition of ventricular remodeling.
Title: Thioredoxin and ventricular remodeling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase (NAD(P)H) activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase (NAD(P)H) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin domain-containing protein 17

Names: 14 kDa thioredoxin-related protein; protein 42-9-9; putative 42-9-9 protein; thioredoxin-like 5; thioredoxin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026559.3 → NP_080835.1 thioredoxin domain-containing protein 17

See identical proteins and their annotated locations for NP_080835.1

Status: VALIDATED

Source sequence(s)

AK076425

Consensus CDS

CCDS24980.1

UniProtKB/Swiss-Prot

Q3TE14, Q921A9, Q9CQM5, Q9D0Y4

Related

ENSMUSP00000021158.4, ENSMUST00000021158.4

Conserved Domains (1) summary

cd02952
Location:4 → 121

TRP14_like; Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. ...