etv6 ETS variant transcription factor 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: etv6provided by ZNC
Official Full Name: ETS variant transcription factor 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-010727-1
See related: AllianceGenome:ZFIN:ZDB-GENE-010727-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tel; id:ibd2308
Summary: Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within embryonic hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including brain; germ ring; intermediate cell mass of mesoderm; mesoderm; and renal system. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and thrombocytopenia. Orthologous to human ETV6 (ETS variant transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: Un

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003337254.2 (5152..5447, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003337254.2 (5152..5447, complement)

NW_003337254.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dominant-negative truncated ETV6 with deletions of the ETS domain or the PNT domain interfered with repression by full-length ETV6 and affected expression of early hematopoietic and erythroid markers in embryos.
Title: Functional analysis of truncated forms of ETV6.
the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system
Title: Control of endothelial sprouting by a Tel-CtBP complex.

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General gene information

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Markers

fc03a10.x1 (e-PCR)
- UniSTS:192094

fc03a10.x1 (e-PCR)
- UniSTS:192095

fj31c02.y1 (e-PCR)
- UniSTS:199037

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor ETV6

Names: ets variant gene 6 (TEL oncogene); ztel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131832.2 → NP_571907.2 transcription factor ETV6

See identical proteins and their annotated locations for NP_571907.2

Status: PROVISIONAL

Source sequence(s)

BC045451

UniProtKB/TrEMBL

Q7ZU22

Conserved Domains (2) summary

cd08535
Location:56 → 123

SAM_PNT-Tel_Yan; Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein

smart00413
Location:331 → 417

ETS; erythroblast transformation specific domain