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    Mtnap1 mitochondrial nucleoid associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 276852, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtnap1provided by MGI
    Official Full Name
    mitochondrial nucleoid associated protein 1provided by MGI
    Primary source
    MGI:MGI:106356
    See related
    Ensembl:ENSMUSG00000041623 AllianceGenome:MGI:106356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm57859; D11Wsu47e
    Summary
    Involved in cell population proliferation; mitochondrial DNA metabolic process; and positive regulation of mitochondrial DNA replication. Located in mitochondrial nucleoid. Orthologous to human MTNAP1 (mitochondrial nucleoid associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 66.6), CNS E11.5 (RPKM 6.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtnap1 in Genome Data Viewer
    Location:
    11 E2; 11 79.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113574490..113590201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113684153..113699375)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 11 Neighboring gene STARR-positive B cell enhancer ABC_E4012 Neighboring gene somatostatin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene STARR-seq mESC enhancer starr_31100 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene STARR-seq mESC enhancer starr_31103 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene cleavage and polyadenylation specific factor 4-like Neighboring gene STARR-positive B cell enhancer ABC_E8469 Neighboring gene CDC42 effector protein 4 Neighboring gene predicted gene 11736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C17orf80 binds the mitochondrial genome to promote its replication. Wu H, et al. J Cell Biol, 2023 Oct 2. PMID 37676315, Free PMC Article
    2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30773, MGC57008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial nucleoid-associated protein 1; uncharacterized protein C17orf80 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361593.1 → NP_001348522.1  mitochondrial nucleoid-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AL603706
      Consensus CDS
      CCDS48976.1
      UniProtKB/Swiss-Prot
      Q3UTJ1, Q6PIX9, Q80UV5, Q9CYN0
      Related
      ENSMUSP00000102232.4, ENSMUST00000106621.4

    2. NM_177777.6 → NP_808445.2  mitochondrial nucleoid-associated protein 1

      See identical proteins and their annotated locations for NP_808445.2

      Status: VALIDATED

      Source sequence(s)
      AL603706
      Consensus CDS
      CCDS48976.1
      UniProtKB/Swiss-Prot
      Q3UTJ1, Q6PIX9, Q80UV5, Q9CYN0
      Related
      ENSMUSP00000042025.9, ENSMUST00000042227.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      113574490..113590201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249059.4 → XP_011247361.1  uncharacterized protein C17orf80 homolog isoform X2

      See identical proteins and their annotated locations for XP_011247361.1

      UniProtKB/Swiss-Prot
      Q3UTJ1, Q6PIX9, Q80UV5, Q9CYN0

    2. XM_017314574.3 → XP_017170063.1  uncharacterized protein C17orf80 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q6PIX9

    3. XM_017314577.3 → XP_017170066.1  uncharacterized protein C17orf80 homolog isoform X3

    4. XM_017314578.3 → XP_017170067.1  uncharacterized protein C17orf80 homolog isoform X5

    5. XM_017314575.3 → XP_017170064.1  uncharacterized protein C17orf80 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q6PIX9

    6. XM_017314576.3 → XP_017170065.1  uncharacterized protein C17orf80 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q6PIX9

    7. XM_030246052.2 → XP_030101912.1  uncharacterized protein C17orf80 homolog isoform X3

    8. XM_011249061.4 → XP_011247363.1  uncharacterized protein C17orf80 homolog isoform X4

    RNA

    1. XR_004936975.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PIX9.3 GenPept UniProtKB/Swiss-Prot:Q6PIX9

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