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    Rasl10b RAS-like, family 10, member B [ Mus musculus (house mouse) ]

    Gene ID: 276952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasl10bprovided by MGI
    Official Full Name
    RAS-like, family 10, member Bprovided by MGI
    Primary source
    MGI:MGI:2685575
    See related
    Ensembl:ENSMUSG00000020684 AllianceGenome:MGI:2685575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm729; VTS58635; B230331P10Rik
    Summary
    Predicted to enable G protein activity and GTP binding activity. Involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; heart; myotome; neural tube; and retina. Orthologous to human RASL10B (RAS like family 10 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 63.2), cortex adult (RPKM 46.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasl10b in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83299963..83311865)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83409137..83421039)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8435 Neighboring gene expressed sequence AA465934 Neighboring gene STARR-seq mESC enhancer starr_30193 Neighboring gene expressed sequence AI450353 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene adaptor-related protein complex 2, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_30196 Neighboring gene predicted gene, 23951 Neighboring gene RIKEN cDNA 1700020L24 gene Neighboring gene growth arrest-specific 2 like 2 Neighboring gene matrix metallopeptidase 28 (epilysin)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Rybkin II, et al. J Cell Biol, 2007 Nov 5. PMID 17984325, Free PMC Article
    2. Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice. Shigesawa I, et al. J Diabetes Investig, 2024 Dec. PMID 39305123, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of peptide hormone secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-like protein family member 10B
    NP_001013404.1
    NP_001348495.1
    NP_001348496.1
    NP_001348497.1
    XP_030101915.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013386.3 → NP_001013404.1  ras-like protein family member 10B isoform 1

      See identical proteins and their annotated locations for NP_001013404.1

      Status: VALIDATED

      Source sequence(s)
      AL663096
      Consensus CDS
      CCDS25163.1
      UniProtKB/Swiss-Prot
      Q5SSG5
      Related
      ENSMUSP00000132696.2, ENSMUST00000164425.2
      Conserved Domains (1) summary
      cd04142
      Location:5 → 203
      RRP22; Ras-related protein on chromosome 22 (RRP22) family

    2. NM_001361566.1 → NP_001348495.1  ras-like protein family member 10B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK045997, AK158941, AW456843, BC116407, BY277818
      Consensus CDS
      CCDS25163.1
      UniProtKB/Swiss-Prot
      Q5SSG5
      Related
      ENSMUSP00000021022.4, ENSMUST00000021022.10
      Conserved Domains (1) summary
      cd04142
      Location:5 → 203
      RRP22; Ras-related protein on chromosome 22 (RRP22) family

    3. NM_001361567.1 → NP_001348496.1  ras-like protein family member 10B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK045997, AK158941, AW456843
      Consensus CDS
      CCDS88208.1
      UniProtKB/TrEMBL
      H3BLI7
      Related
      ENSMUSP00000135803.2, ENSMUST00000175848.8
      Conserved Domains (1) summary
      cl21455
      Location:5 → 117
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001361568.1 → NP_001348497.1  ras-like protein family member 10B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK045997, AK158941, AW456843, BE995698
      Consensus CDS
      CCDS25163.1
      UniProtKB/Swiss-Prot
      Q5SSG5
      Related
      ENSMUSP00000103775.4, ENSMUST00000108140.10
      Conserved Domains (1) summary
      cd04142
      Location:5 → 203
      RRP22; Ras-related protein on chromosome 22 (RRP22) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83299963..83311865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246055.2 → XP_030101915.1  ras-like protein family member 10B isoform X1

      UniProtKB/Swiss-Prot
      Q5SSG5
      Conserved Domains (1) summary
      cd04142
      Location:5 → 203
      RRP22; Ras-related protein on chromosome 22 (RRP22) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SSG5.1 GenPept UniProtKB/Swiss-Prot:Q5SSG5

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