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    Pde1c phosphodiesterase 1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81742, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Pde1cprovided by RGD
    Official Full Name
    phosphodiesterase 1Cprovided by RGD
    Primary source
    RGD:68332
    See related
    EnsemblRapid:ENSRNOG00000012337 AllianceGenome:RGD:68332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cAMP binding activity; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 43.5), Kidney (RPKM 40.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde1c in Genome Data Viewer
    Location:
    4q24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (86629074..87108147, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (85300858..85777948, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (86359762..86925044, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 17 Neighboring gene uncharacterized LOC134486774 Neighboring gene apolipoprotein O, pseudogene 4 Neighboring gene transfer RNA serine (anticodon AGA) 44 Neighboring gene transfer RNA threonine (anticodon AGU) 9 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C. Sun W, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Mar 25. PMID 35538034, Free PMC Article
    2. Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells. Cai Y, et al. Arterioscler Thromb Vasc Biol, 2011 Mar. PMID 21148428, Free PMC Article
    3. Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia. Cai Y, et al. Circ Res, 2015 Mar 27. PMID 25608528, Free PMC Article
    4. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. Santone R, et al. J Neurosci Res, 2006 Oct. PMID 16881052
    5. Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Cygnar KD, et al. Nat Neurosci, 2009 Apr. PMID 19305400, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C.
      Title: Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C.
    2. In cultured rat aortic SMCs, PDE1C deficiency or PDE1 inhibition attenuated SMC proliferation and migration. PDE1C plays a critical role in regulating the stability of growth factor receptors, endocytosis and lysosome-dependent degradation.
      Title: Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.
    3. Suggest that PDE1C plays a critical role in regulating collagen homeostasis during pathological vascular remodeling.
      Title: Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    Names
    3',5'-cyclic-AMP phosphodiesterase
    3',5'-cyclic-GMP phosphodiesterase
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    cam-PDE 1C
    cyclic nucleotide phosphodiesterase 1 C
    dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
    phosphodiesterase 1C calmodulin-dependent (70kD)
    NP_112340.1
    XP_008761144.2
    XP_038964360.1
    XP_038964361.1
    XP_038964362.1
    XP_038964363.1
    XP_063142821.1
    XP_063142822.1
    XP_063142823.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031078.2 → NP_112340.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

      Status: PROVISIONAL

      Source sequence(s)
      L41045
      UniProtKB/Swiss-Prot
      Q63421
      UniProtKB/TrEMBL
      A0A8I6AQQ1, A6K104
      Related
      ENSRNOP00000096395.2, ENSRNOT00000098186.2
      Conserved Domains (2) summary
      pfam00233
      Location:287 → 515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146 → 202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      86629074..87108147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762922.4 → XP_008761144.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K105, F1LMX4
      Conserved Domains (3) summary
      PTZ00121
      Location:543 → 635
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:227 → 455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. XM_039108434.2 → XP_038964362.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K105, F1LMX4
      Related
      ENSRNOP00000017531.8, ENSRNOT00000017531.9
      Conserved Domains (3) summary
      PTZ00121
      Location:543 → 635
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:227 → 455
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:86 → 142
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. XM_039108433.2 → XP_038964361.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQQ1, A6K104
      Conserved Domains (3) summary
      PTZ00121
      Location:603 → 695
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:287 → 515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146 → 202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    4. XM_039108432.2 → XP_038964360.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQQ1, A6K104
      Related
      ENSRNOP00000099233.1, ENSRNOT00000146532.1
      Conserved Domains (3) summary
      PTZ00121
      Location:603 → 695
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:287 → 515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146 → 202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    5. XM_063286751.1 → XP_063142821.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A0A8I6AMU0, A6K107
      Related
      ENSRNOP00000099194.1, ENSRNOT00000167670.1

    6. XM_039108435.2 → XP_038964363.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8V6, A0A8I6AQQ1, A6K104
      Related
      ENSRNOP00000089783.1, ENSRNOT00000118567.2
      Conserved Domains (3) summary
      PTZ00121
      Location:603 → 690
      PTZ00121; MAEBL; Provisional
      pfam00233
      Location:287 → 515
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:146 → 202
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    7. XM_063286753.1 → XP_063142823.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K108
      Related
      ENSRNOP00000077659.1, ENSRNOT00000098034.2

    8. XM_063286752.1 → XP_063142822.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y1F5, A6K108
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63421.1 GenPept UniProtKB/Swiss-Prot:Q63421

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