Mrm1 mitochondrial rRNA methyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrm1provided by MGI
Official Full Name: mitochondrial rRNA methyltransferase 1provided by MGI
Primary source: MGI:MGI:2443470
See related: Ensembl:ENSMUSG00000018405 AllianceGenome:MGI:2443470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A530065E19Rik
Summary: Predicted to enable rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA modification. Located in mitochondrion. Orthologous to human MRM1 (mitochondrial rRNA methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 14.2), liver E14 (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.34 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (84703887..84710341, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (84813061..84819515, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit.
Title: Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables rRNA (guanine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (guanosine-2'-O-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (guanosine-2'-O-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in rRNA 2'-O-methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA modification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rRNA methyltransferase 1, mitochondrial

Names: 16S rRNA (guanosine(1145)-2'-O)-methyltransferase; 16S rRNA [Gm1145] 2'-O-methyltransferase; mitochondrial large ribosomal RNA ribose methylase; mitochondrial rRNA methyltransferase 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145433.1 → NP_663408.2 rRNA methyltransferase 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_663408.2

Status: VALIDATED

Source sequence(s)

BC005625

Consensus CDS

CCDS36260.1

UniProtKB/Swiss-Prot

Q3TPX8, Q3U0Z5, Q5ND22, Q99J25

Related

ENSMUSP00000018549.8, ENSMUST00000018549.8

Conserved Domains (2) summary

cd18105
Location:144 → 301

SpoU-like_MRM1; SAM-dependent rRNA methylase related to MRM1

pfam08032
Location:85 → 125

SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding