Hnrnpk heterogeneous nuclear ribonucleoprotein K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpkprovided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein Kprovided by MGI
Primary source: MGI:MGI:99894
See related: Ensembl:ENSMUSG00000021546 AllianceGenome:MGI:99894
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KBBP; NOVA; Hnrpk
Summary: The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 240.5), CNS E14 (RPKM 167.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 31.04 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (58538946..58551157, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (58391132..58403343, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Title: Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.
Title: Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.
HnRNPK is involved in stress-induced depression-like behavior via ERK-BDNF pathway in mice.
Title: HnRNPK is involved in stress-induced depression-like behavior via ERK-BDNF pathway in mice.
Deletion of Hnrnpk Gene Causes Infertility in Male Mice by Disrupting Spermatogenesis.
Title: Deletion of Hnrnpk Gene Causes Infertility in Male Mice by Disrupting Spermatogenesis.
hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages.
Title: hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages.
hnRNP-K localizes exclusively within open chromatin, implying its role in the onset and/or maintenance of this chromatin state.
Title: hnRNP-K Targets Open Chromatin in Mouse Embryonic Stem Cells in Concert with Multiple Regulators.
hnRNP K plays a protective role in TNF-alpha-induced apoptosis in podocytes.
Title: hnRNP K plays a protective role in TNF-α-induced apoptosis in podocytes.
The expression analysis of key cell cycle regulators indicated mRNA of Cyclin A2 was significantly increased in the hnRNPK-mutated cells compared to the control cells, while Cyclin B1, Cdc25b and Cdc25c were decreased sharply.
Title: The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts.
This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK in FTO-associated transformations.
Title: Exogenous Expressions of FTO Wild-Type and R316Q Mutant Proteins Caused an Increase in HNRPK Levels in 3T3-L1 Cells as Demonstrated by DIGE Analysis.
hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing.
Title: hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HNRPK-1 (e-PCR)
- UniSTS:511804

Hnrpk (e-PCR), detects polymorphism
- UniSTS:479126

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables C-rich single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA 3'-splice site binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of branching morphogenesis of a nerve	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of low-density lipoprotein receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in random inactivation of X chromosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated heterochromatin formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in podosome	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301340.1 → NP_001288269.1 heterogeneous nuclear ribonucleoprotein K isoform 1

See identical proteins and their annotated locations for NP_001288269.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AK011428, AK160615, AV367088, BC089328, BE993983

Consensus CDS

CCDS79199.1

UniProtKB/TrEMBL

Q3TL71, Q5FWJ5

Related

ENSMUSP00000153253.2, ENSMUST00000224182.2

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001301341.1 → NP_001288270.1 heterogeneous nuclear ribonucleoprotein K isoform 1

See identical proteins and their annotated locations for NP_001288270.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AK078777, AV367088, BC089328, BE993983

Consensus CDS

CCDS79199.1

UniProtKB/TrEMBL

Q3TL71, Q5FWJ5

Related

ENSMUSP00000112104.3, ENSMUST00000116403.9

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001301343.1 → NP_001288272.1 heterogeneous nuclear ribonucleoprotein K isoform 1

See identical proteins and their annotated locations for NP_001288272.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AK166927, AV367088, BC089328, BE993983, BY794631

Consensus CDS

CCDS79199.1

UniProtKB/TrEMBL

Q3TL71, Q5FWJ5

Related

ENSMUSP00000152935.2, ENSMUST00000225674.2

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001301344.1 → NP_001288273.1 heterogeneous nuclear ribonucleoprotein K isoform 3

See identical proteins and their annotated locations for NP_001288273.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an in-frame exon compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.

Source sequence(s)

AK011428, AK051313, AK151689, AK160615, AV367088, BC089328, BE993983

Consensus CDS

CCDS79198.1

UniProtKB/TrEMBL

B2M1R6, Q3TL71

Related

ENSMUSP00000135647.2, ENSMUST00000177019.8

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:120 → 189

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:363 → 436

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001301345.1 → NP_001288274.1 heterogeneous nuclear ribonucleoprotein K isoform 4

See identical proteins and their annotated locations for NP_001288274.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternative splice site in the 3' terminal exon, which results in a frameshift, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK011428, AK051313, AV367088, BC089328, BE993983

Consensus CDS

CCDS79197.1

UniProtKB/TrEMBL

Q3U6X2

Related

ENSMUSP00000135354.2, ENSMUST00000176207.8

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:120 → 189

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:363 → 436

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001360490.1 → NP_001347419.1 heterogeneous nuclear ribonucleoprotein K isoform 2

Status: REVIEWED

Source sequence(s)

AC154437

Consensus CDS

CCDS49283.1

UniProtKB/Swiss-Prot

P61979, Q8BGQ8

UniProtKB/TrEMBL

Q3TJ38, Q3TUA1

Related

ENSMUSP00000135833.2, ENSMUST00000177497.8

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001360491.1 → NP_001347420.1 heterogeneous nuclear ribonucleoprotein K isoform 5

Status: REVIEWED

Source sequence(s)

AC154437

UniProtKB/TrEMBL

Q3TL71

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:382 → 455

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001360493.1 → NP_001347422.1 heterogeneous nuclear ribonucleoprotein K isoform 6

Status: REVIEWED

Source sequence(s)

AC154437

UniProtKB/TrEMBL

Q3TJ38, Q3TUA1

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:382 → 455

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001360494.1 → NP_001347423.1 heterogeneous nuclear ribonucleoprotein K isoform 3

Status: REVIEWED

Source sequence(s)

AC154437

Consensus CDS

CCDS79198.1

UniProtKB/TrEMBL

B2M1R6, Q3TL71

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:120 → 189

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:363 → 436

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_001360495.1 → NP_001347424.1 heterogeneous nuclear ribonucleoprotein K isoform 4

Status: REVIEWED

Source sequence(s)

AC154437

Consensus CDS

CCDS79197.1

UniProtKB/TrEMBL

Q3U6X2

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:120 → 189

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:363 → 436

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
NM_025279.3 → NP_079555.1 heterogeneous nuclear ribonucleoprotein K isoform 2

See identical proteins and their annotated locations for NP_079555.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternative splice site in the 3' terminal exon, which results in a frameshift, compared to variant 1. It encodes isoform 2 which has a distinct and shorter C-terminus compared to isoform 1.

Source sequence(s)

AK011428, AV367088, BC089328, BE993983

Consensus CDS

CCDS49283.1

UniProtKB/Swiss-Prot

P61979, Q8BGQ8

UniProtKB/TrEMBL

Q3TJ38, Q3TUA1

Related

ENSMUSP00000039269.8, ENSMUST00000043269.14

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

RNA

NR_153501.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC154437
NR_153502.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC154437
NR_153503.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC154437
NR_153504.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC154437

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

58538946..58551157 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517103.5 → XP_006517166.1 heterogeneous nuclear ribonucleoprotein K isoform X1

See identical proteins and their annotated locations for XP_006517166.1

UniProtKB/TrEMBL

Q3TL71, Q5FWJ5

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
XM_006517104.4 → XP_006517167.1 heterogeneous nuclear ribonucleoprotein K isoform X1

See identical proteins and their annotated locations for XP_006517167.1

UniProtKB/TrEMBL

Q3TL71, Q5FWJ5

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins