Igf2r insulin-like growth factor 2 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igf2rprovided by MGI
Official Full Name: insulin-like growth factor 2 receptorprovided by MGI
Primary source: MGI:MGI:96435
See related: Ensembl:ENSMUSG00000023830 AllianceGenome:MGI:96435
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD222; CI-MPR; Mpr300; M6P/IGF2R
Summary: Enables D-mannose binding activity and insulin-like growth factor binding activity. Predicted to be involved in several processes, including liver development; positive regulation by host of viral process; and response to retinoic acid. Located in membrane and nuclear envelope lumen. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 34.0), placenta adult (RPKM 24.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 8.64 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (12901293..12988593, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (12682406..12769706, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.
Title: The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.
Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.
Title: Different dietary combinations of folic acid and vitamin B12 in parental diet results in epigenetic reprogramming of IGF2R and KCNQ1OT1 in placenta and fetal tissues in mice.
Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells.
Title: Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells.
Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.
Title: Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.
A role for CIM6P/IGF2 receptor in memory consolidation and enhancement.
Title: A role for CIM6P/IGF2 receptor in memory consolidation and enhancement.
Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2r(I1565A)) results in partial lethality, overgrowth and intestinal adenoma progression.
Title: Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2r(I1565A)) results in partial lethality, overgrowth and intestinal adenoma progression.
Igf2bp2 is a binding partner of Airn in cardiomyocytes. Airn binds to Igf2bp2 to control the translation of several genes. Silencing of Airn caused less binding of Igf2bp2 to other mRNAs and reduced translation of Igf2bp2 protein.
Title: Airn Regulates Igf2bp2 Translation in Cardiomyocytes.
After 6 weeks of environmental tobacco smoke exposure, the Sirt-1 protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced.
Title: Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts.
Selective M6PR down-regulation has a critical role in CD8(+) T cell survival.
Title: Differential expression of mannose-6-phosphate receptor regulates T cell contraction.
Expression of imprinted gene Igf2r was unregulated in haploid androgenetic/gynogenetic blastocysts.
Title: Analysis of imprinted gene expression and implantation in haploid androgenetic mouse embryos.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237576

Igf2r (e-PCR), detects polymorphism
- UniSTS:470559

25.mHAa3f1.seq (e-PCR)
- UniSTS:123708

Igf2r (e-PCR), detects polymorphism
- UniSTS:516449

Igf2r (e-PCR), detects polymorphism
- UniSTS:143483

Igf2r (e-PCR), detects polymorphism
- UniSTS:143484

Igf2r (e-PCR), detects polymorphism
- UniSTS:143485

Airn (e-PCR), detects polymorphism
- UniSTS:532130

Airn (e-PCR), detects polymorphism
- UniSTS:532131

Igf2r (e-PCR), detects polymorphism
- UniSTS:532140

Igf2r (e-PCR), detects polymorphism
- UniSTS:532141

Igf2r (e-PCR), detects polymorphism
- UniSTS:516549

PMC136958P1 (e-PCR)
- UniSTS:270810

PMC136958P2 (e-PCR)
- UniSTS:270811

Igf2r (e-PCR), detects polymorphism
- UniSTS:259555

AI661837 (e-PCR)
- UniSTS:186086

Igf2r (e-PCR), detects polymorphism
- UniSTS:516605

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables retinoic acid binding	IEA Inferred from Electronic Annotation more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables retromer complex binding	IEA Inferred from Electronic Annotation more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosomal transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in response to tetrachloromethane	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
part_of clathrin coat	IEA Inferred from Electronic Annotation more info
part_of clathrin coat	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cation-independent mannose-6-phosphate receptor

Names: 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; IGF-II/CI-MPR; M6P/IGF2 receptor; M6PR; MPR 300; cation-independent MPR; insulin-like growth factor II receptor; mannose-6-phosphate receptor, cation independent

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010515.2 → NP_034645.2 cation-independent mannose-6-phosphate receptor precursor

See identical proteins and their annotated locations for NP_034645.2

Status: VALIDATED

Source sequence(s)

AC116804, AC167817, AK053045, BB865604, BP757292, BQ900123, CA324933, CD545656, CF167933, CK639250, CN461279, CN530622

Consensus CDS

CCDS37436.1

UniProtKB/Swiss-Prot

Q07113, Q61822, Q6LED1

UniProtKB/TrEMBL

B7ZWC4

Related

ENSMUSP00000024599.8, ENSMUST00000024599.14

Conserved Domains (3) summary

cd00062
Location:1890 → 1935

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

pfam00878
Location:1024 → 1171

CIMR; Cation-independent mannose-6-phosphate receptor repeat

pfam09451
Location:335 → 467

ATG27; Autophagy-related protein 27