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    Cmbl carboxymethylenebutenolidase homolog [ Mus musculus (house mouse) ]

    Gene ID: 69574, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cmblprovided by MGI
    Official Full Name
    carboxymethylenebutenolidase homologprovided by MGI
    Primary source
    MGI:MGI:1916824
    See related
    Ensembl:ENSMUSG00000022235 AllianceGenome:MGI:1916824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310016A09Rik
    Summary
    Predicted to enable hydrolase activity. Predicted to be located in cytosol. Is expressed in adrenal medulla and nervous system. Orthologous to human CMBL (carboxymethylenebutenolidase homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 53.1), kidney adult (RPKM 44.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cmbl in Genome Data Viewer
    Location:
    15 B2; 15 13.0 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31565314..31590266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31565342..31590119)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10847 Neighboring gene ropporin 1-like Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene predicted gene, 49208 Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene STARR-seq mESC enhancer starr_38292 Neighboring gene STARR-positive B cell enhancer ABC_E4130 Neighboring gene chaperonin containing TCP1 subunit 5 Neighboring gene ATP synthase C subunit lysine N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gene expression resource generated by genome-wide lacZ profiling in the mouse. Tuck E, et al. Dis Model Mech, 2015 Nov. PMID 26398943, Free PMC Article
    2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxymethylenebutenolidase homolog
    Names
    carboxymethylenebutenolidase-like (Pseudomonas)
    NP_853619.1
    XP_006520239.1
    XP_006520240.1
    XP_006520241.1
    XP_030104612.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181588.4 → NP_853619.1  carboxymethylenebutenolidase homolog

      See identical proteins and their annotated locations for NP_853619.1

      Status: VALIDATED

      Source sequence(s)
      AI426411, BB863032, BM899338, BY793531
      Consensus CDS
      CCDS27410.1
      UniProtKB/Swiss-Prot
      Q8C1N1, Q8R1G2
      UniProtKB/TrEMBL
      A0A2I3BPJ4
      Related
      ENSMUSP00000070314.7, ENSMUST00000070918.14
      Conserved Domains (1) summary
      COG0412
      Location:30 → 244
      DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      31565314..31590266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520176.4 → XP_006520239.1  carboxymethylenebutenolidase homolog isoform X1

      See identical proteins and their annotated locations for XP_006520239.1

      UniProtKB/Swiss-Prot
      Q8C1N1, Q8R1G2
      UniProtKB/TrEMBL
      A0A2I3BPJ4
      Related
      ENSMUSP00000153812.2, ENSMUST00000226951.2
      Conserved Domains (1) summary
      COG0412
      Location:30 → 244
      DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]

    2. XM_030248752.2 → XP_030104612.1  carboxymethylenebutenolidase homolog isoform X2

      UniProtKB/TrEMBL
      E0CXH4
      Conserved Domains (1) summary
      cl21494
      Location:30 → 157
      Abhydrolase; alpha/beta hydrolases

    3. XM_006520178.5 → XP_006520241.1  carboxymethylenebutenolidase homolog isoform X2

      UniProtKB/TrEMBL
      E0CXH4
      Conserved Domains (1) summary
      cl21494
      Location:30 → 157
      Abhydrolase; alpha/beta hydrolases

    4. XM_006520177.5 → XP_006520240.1  carboxymethylenebutenolidase homolog isoform X1

      See identical proteins and their annotated locations for XP_006520240.1

      UniProtKB/Swiss-Prot
      Q8C1N1, Q8R1G2
      UniProtKB/TrEMBL
      A0A2I3BPJ4
      Conserved Domains (1) summary
      COG0412
      Location:30 → 244
      DLH; Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1G2.1 GenPept UniProtKB/Swiss-Prot:Q8R1G2

    Gene LinkOut

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