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    Vdac2 voltage-dependent anion channel 2 [ Mus musculus (house mouse) ]

    Gene ID: 22334, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vdac2provided by MGI
    Official Full Name
    voltage-dependent anion channel 2provided by MGI
    Primary source
    MGI:MGI:106915
    See related
    Ensembl:ENSMUSG00000021771 AllianceGenome:MGI:106915
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vdac6; mVDAC2; mVDAC6
    Summary
    Enables oxysterol binding activity. Involved in negative regulation of intrinsic apoptotic signaling pathway and negative regulation of protein polymerization. Located in mitochondrion and sperm midpiece. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 152.6), adrenal adult (RPKM 132.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Vdac2 in Genome Data Viewer
    Location:
    14 A3; 14 11.91 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21881629..21895947)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21831561..21845879)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10820 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene predicted gene, 23502 Neighboring gene RIKEN cDNA A430057M04 gene Neighboring gene STARR-positive B cell enhancer mm9_chr14:22668101-22668402 Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_36154 Neighboring gene STARR-seq mESC enhancer starr_36155 Neighboring gene zinc finger protein 503

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxysterol binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    voltage-dependent anion-selective channel protein 2
    Names
    VDAC-2
    VDAC-6
    outer mitochondrial membrane protein porin 2
    voltage-dependent anion-selective channel protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011695.2NP_035825.1  voltage-dependent anion-selective channel protein 2

      See identical proteins and their annotated locations for NP_035825.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132590, AC151533
      Consensus CDS
      CCDS26867.1
      UniProtKB/Swiss-Prot
      Q60930, Q78MH6, Q99L98
      UniProtKB/TrEMBL
      G3UX26
      Related
      ENSMUSP00000022293.8, ENSMUST00000022293.14
      Conserved Domains (1) summary
      cd07306
      Location:16294
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21881629..21895947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)