Oxct1 3-oxoacid CoA transferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxct1provided by MGI
Official Full Name: 3-oxoacid CoA transferase 1provided by MGI
Primary source: MGI:MGI:1914291
See related: Ensembl:ENSMUSG00000022186 AllianceGenome:MGI:1914291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oxct; SCOT; Oxct2a; Scot-s; 2610008O03Rik
Summary: Enables succinyl-CoA:3-oxo-acid CoA-transferase activity. Acts upstream of or within ketone body catabolic process and ketone catabolic process. Located in mitochondrion. Is expressed in foregut and heart. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 155.7), heart adult (RPKM 139.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 1.86 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (4055910..4184826)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (4026428..4155344)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3beta/beta-catenin pathway after subarachnoid hemorrhage.
Title: OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3β/β-catenin pathway after subarachnoid hemorrhage.
Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
Title: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
Neuroprotective mechanisms of OXCT1 via the SIRT3-SOD2 pathway after traumatic brain injury.
Title: Neuroprotective mechanisms of OXCT1 via the SIRT3-SOD2 pathway after traumatic brain injury.
These results suggest that MT prevention of diabetes-induced pathological changes in cardiac tissues is most likely mediated by suppression of SCOT nitration at Trp(374).
Title: Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374).
Data suggest that to sustain survival and euglycemia during moderate-duration starvation, ketone body oxidation via Oxct1 is not required for energy transfer in three cell types: neurons, skeletal myocytes, and cardiomyocytes.
Title: Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation.
Although Oxct1(-/-) mice exhibit normal prenatal development, all develop ketoacidosis, hypoglycemia, and reduced plasma lactate concentrations within the first 48 h of birth
Title: Obligate role for ketone body oxidation in neonatal metabolic homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Oxct1 (e-PCR), detects polymorphism
- UniSTS:546910

Oxct1 (e-PCR), detects polymorphism
- UniSTS:515977

AA819087 (e-PCR)
- UniSTS:243438

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ketone body catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ketone body metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ketone body metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ketone body metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ketone catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Names: somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid CoA transferase; succinyl-CoA:3-oxoacid CoA transferase

NP_077150.1

EC 2.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024188.6 → NP_077150.1 succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_077150.1

Status: VALIDATED

Source sequence(s)

AK078086, AK151662, AK167681, BE952161

Consensus CDS

CCDS27361.1

UniProtKB/Swiss-Prot

Q3TIW6, Q9CV92, Q9D0K2

UniProtKB/TrEMBL

Q3U9P7, Q3UK61

Related

ENSMUSP00000106318.3, ENSMUST00000110690.9

Conserved Domains (3) summary

COG1788
Location:41 → 274

AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

COG4670
Location:48 → 517

YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]

cl00339
Location:300 → 508

SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...