Hmgb2l1 high mobility group box 2-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hmgb2l1provided by RGD
Official Full Name: high mobility group box 2-like 1provided by RGD
Primary source: RGD:1564519
See related: EnsemblRapid:ENSRNOG00000033321 AllianceGenome:RGD:1564519
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HMG2; RGD1564519
Summary: Predicted to enable DNA binding activity. Predicted to be involved in several processes, including DNA topological change; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including chromosome; extracellular space; and perinuclear region of cytoplasm. Orthologous to human HMGB2 (high mobility group box 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: 11q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (60721545..60722608, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (47252583..47253646, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (49708038..49709128, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:224572

RH126943 (e-PCR)
- UniSTS:209768

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding, bending	ISS Inferred from Sequence or Structural Similarity more info
enables cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables non-sequence-specific DNA binding, bending	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables supercoiled DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA topological change	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in defense response to Gram-negative bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to Gram-positive bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response to antigenic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in condensed chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: high mobility group box 2-like 1

Names: high mobility group protein B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329881.2 → NP_001316810.1 high mobility group box 2-like 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P52925, Q5FVP0

UniProtKB/TrEMBL

A6KIU7, D3ZN59

Related

ENSRNOP00000039358.2, ENSRNOT00000046874.4

Conserved Domains (2) summary

pfam00505
Location:95 → 162

HMG_box; HMG (high mobility group) box

pfam09011
Location:6 → 78

HMG_box_2; HMG-box domain