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    MIB2 MIB E3 ubiquitin protein ligase 2 [ Piliocolobus tephrosceles (Ugandan red Colobus) ]

    Gene ID: 111535085, updated on 15-Mar-2024

    Summary

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    Gene symbol
    MIB2
    Gene description
    MIB E3 ubiquitin protein ligase 2
    See related
    Ensembl:ENSPTEG00000016986
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Piliocolobus tephrosceles
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Piliocolobus
    Orthologs
    human mouse all
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    Genomic context

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    See MIB2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    102 current ASM277652v3 (GCF_002776525.3) 1 NC_045434.1 (220190255..220204731, complement)
    100 previous assembly ASM277652v1 (GCF_002776525.1) Unplaced Scaffold NW_019360801.1 (404..16537, complement)

    Chromosome 1 - NC_045434.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 11B Neighboring gene matrix metallopeptidase 23B Neighboring gene fibronectin type III domain containing 10 Neighboring gene SSU72 homolog, RNA polymerase II CTD phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MIB2
    Names
    mindbomb E3 ubiquitin protein ligase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Piliocolobus tephrosceles Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM277652v3

    Genomic

    1. NC_045434.1 Reference ASM277652v3

      Range
      220190255..220204731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031934847.1 → XP_031790707.1  E3 ubiquitin-protein ligase MIB2 isoform X2

      UniProtKB/TrEMBL
      A0A8C9H3K0
      Conserved Domains (8) summary
      PTZ00322
      Location:394 → 514
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA03095
      Location:457 → 708
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:461 → 491
      ANK; ANK repeat [structural motif]
      cd16726
      Location:827 → 863
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:324 → 388
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:906 → 951
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_031934848.1 → XP_031790708.1  E3 ubiquitin-protein ligase MIB2 isoform X3

      UniProtKB/TrEMBL
      A0A8C9H3K0
      Conserved Domains (8) summary
      PTZ00322
      Location:363 → 483
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA03095
      Location:426 → 677
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:430 → 460
      ANK; ANK repeat [structural motif]
      cd16726
      Location:796 → 832
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:257 → 322
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:875 → 920
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_023201518.1 → XP_023057286.1  E3 ubiquitin-protein ligase MIB2 isoform X1

      UniProtKB/TrEMBL
      A0A8C9H3K0, A0A8C9H671
      Related
      ENSPTEP00000015306.1, ENSPTET00000022867.1
      Conserved Domains (7) summary
      COG0666
      Location:400 → 521
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:463 → 575
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      cd16726
      Location:831 → 867
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      cl17238
      Location:910 → 955
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_031934849.1 → XP_031790709.1  E3 ubiquitin-protein ligase MIB2 isoform X4

      UniProtKB/TrEMBL
      A0A8C9H920
      Conserved Domains (7) summary
      PTZ00322
      Location:398 → 518
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA03095
      Location:461 → 712
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      cd16726
      Location:831 → 867
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain

    RNA

    1. XR_004228663.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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