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    APP amyloid beta precursor protein [ Piliocolobus tephrosceles (Ugandan red Colobus) ]

    Gene ID: 111524713, updated on 15-Mar-2024

    Summary

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    Gene symbol
    APP
    Gene description
    amyloid beta precursor protein
    See related
    Ensembl:ENSPTEG00000025471
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Piliocolobus tephrosceles
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Piliocolobus
    Orthologs
    human mouse all
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    Genomic context

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    See APP in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    102 current ASM277652v3 (GCF_002776525.3) 19 NC_045452.1 (53170239..53462103)
    100 previous assembly ASM277652v1 (GCF_002776525.1) Unplaced Scaffold NW_019316906.1 (1582971..1868411, complement)

    Chromosome 19 - NC_045452.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene cysteine and tyrosine rich 1 Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic initiation factor 4A-II pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene protein LLP homolog pseudogene Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene ATP synthase peripheral stalk subunit F6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amyloid-beta precursor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Piliocolobus tephrosceles Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM277652v3

    Genomic

    1. NC_045452.1 Reference ASM277652v3

      Range
      53170239..53462103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023190001.1 → XP_023045769.1  amyloid-beta precursor protein isoform X1

      UniProtKB/TrEMBL
      A0A8C9HQQ0, A0A8C9HYK5
      Related
      ENSPTEP00000025159.1, ENSPTET00000035666.1
      Conserved Domains (5) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:295 → 343
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:676 → 714
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:717 → 767
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:367 → 549
      APP_E2; E2 domain of amyloid precursor protein

    2. XM_023190010.1 → XP_023045778.1  amyloid-beta precursor protein isoform X2

      UniProtKB/TrEMBL
      A0A8C9HQQ0, A0A8C9HV19
      Related
      ENSPTEP00000025162.1, ENSPTET00000035671.1
      Conserved Domains (5) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:295 → 343
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:658 → 696
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:699 → 749
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:367 → 549
      APP_E2; E2 domain of amyloid precursor protein

    3. XM_023190020.1 → XP_023045788.1  amyloid-beta precursor protein isoform X3

      UniProtKB/TrEMBL
      A0A8C9HQQ0, A0A8C9I2M0
      Related
      ENSPTEP00000025163.1, ENSPTET00000035672.1
      Conserved Domains (5) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:295 → 343
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:657 → 695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:698 → 748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:348 → 530
      APP_E2; E2 domain of amyloid precursor protein

    4. XM_023190022.1 → XP_023045790.1  amyloid-beta precursor protein isoform X4

      UniProtKB/TrEMBL
      A0A8C9HQQ0
      Conserved Domains (5) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:295 → 343
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:639 → 677
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:680 → 730
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:348 → 530
      APP_E2; E2 domain of amyloid precursor protein

    5. XM_023190025.1 → XP_023045793.1  amyloid-beta precursor protein isoform X5

      UniProtKB/TrEMBL
      A0A8C9HQQ0, A0A8C9HRZ6
      Related
      ENSPTEP00000025166.1, ENSPTET00000035676.1
      Conserved Domains (4) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam03494
      Location:601 → 639
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:642 → 692
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:292 → 474
      APP_E2; E2 domain of amyloid precursor protein

    6. XM_023190030.1 → XP_023045798.1  amyloid-beta precursor protein isoform X6

      UniProtKB/TrEMBL
      A0A8C9HQQ0
      Conserved Domains (4) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam03494
      Location:583 → 621
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:624 → 674
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:292 → 474
      APP_E2; E2 domain of amyloid precursor protein
    Nucleotide Protein
    Heading Accession and Version

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