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    Zfp740 zinc finger protein 740 [ Mus musculus (house mouse) ]

    Gene ID: 68744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp740provided by MGI
    Official Full Name
    zinc finger protein 740provided by MGI
    Primary source
    MGI:MGI:1915994
    See related
    Ensembl:ENSMUSG00000046897 AllianceGenome:MGI:1915994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf740; 1110034O07Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human ZNF740 (zinc finger protein 740). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.0), CNS E14 (RPKM 22.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp740 in Genome Data Viewer
    Location:
    15 F2; 15 57.37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102112080..102124045)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102203506..102215610)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 6 Neighboring gene sterol O-acyltransferase 2 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene STARR-positive B cell enhancer ABC_E5519 Neighboring gene STARR-seq mESC enhancer starr_39822 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055434-102055734 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055789-102056089 Neighboring gene integrin beta 7 Neighboring gene STARR-seq mESC enhancer starr_39826 Neighboring gene STARR-seq mESC enhancer starr_39827 Neighboring gene retinoic acid receptor, gamma Neighboring gene STARR-seq mESC enhancer starr_39828

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Themis2 regulates natural killer cell memory function and formation. Nabekura T, et al. Nat Commun, 2023 Nov 8. PMID 37938555, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 740

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289690.2 → NP_001276619.1  zinc finger protein 740 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC123791
      Conserved Domains (2) summary
      sd00017
      Location:115 → 135
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:127 → 152
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001289691.1 → NP_001276620.1  zinc finger protein 740 isoform 2

      See identical proteins and their annotated locations for NP_001276620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the 5' coding region compared to variant 1. These differences cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC123791
      Consensus CDS
      CCDS79416.1
      UniProtKB/TrEMBL
      A0A2R8W747
      Related
      ENSMUSP00000112985.2, ENSMUST00000118729.8
      Conserved Domains (2) summary
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:90 → 115
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001289694.1 → NP_001276623.1  zinc finger protein 740 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in both UTR's and has multiple coding region differences one of which results in a frameshift compared to variant 1. These differences also cause translation initiation at a downstream start codon compared to variant 1. This results in an isoform (3) that is shorter at the N-terminus and has a distinct C-termini, compared to isoform 1.
      Source sequence(s)
      AC123791
      Consensus CDS
      CCDS79415.1
      UniProtKB/TrEMBL
      D3Z4S9
      Related
      ENSMUSP00000113691.2, ENSMUST00000119168.8

    4. NM_001289695.1 → NP_001276624.1  zinc finger protein 740 isoform 4

      See identical proteins and their annotated locations for NP_001276624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC123791, BC066011
      Consensus CDS
      CCDS70672.1
      UniProtKB/Swiss-Prot
      Q3UMS3, Q6NZQ6, Q8JZR3
      Related
      ENSMUSP00000113770.2, ENSMUST00000119800.8
      Conserved Domains (2) summary
      sd00017
      Location:90 → 110
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:102 → 127
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001358674.1 → NP_001345603.1  zinc finger protein 740 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC123791
      Conserved Domains (2) summary
      sd00017
      Location:103 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:115 → 140
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      102112080..102124045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248732.2 → XP_030104592.1  zinc finger protein 740 isoform X1

      Related
      ENSMUSP00000122698.3, ENSMUST00000141465.9
      Conserved Domains (2) summary
      sd00017
      Location:115 → 135
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:127 → 152
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011245721.1 → XP_011244023.1  zinc finger protein 740 isoform X3

    3. XM_036159565.1 → XP_036015458.1  zinc finger protein 740 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:103 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:115 → 140
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006521336.2 → XP_006521399.1  zinc finger protein 740 isoform X4

      See identical proteins and their annotated locations for XP_006521399.1

      UniProtKB/TrEMBL
      A0A2R8W747
      Related
      ENSMUSP00000155827.2, ENSMUST00000230867.2
      Conserved Domains (2) summary
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:90 → 115
      zf-H2C2_2; Zinc-finger double domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153194.1: Suppressed sequence

      Description
      NM_153194.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZQ6.1 GenPept UniProtKB/Swiss-Prot:Q6NZQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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