U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Alox12b arachidonate 12-lipoxygenase, 12R type [ Mus musculus (house mouse) ]

    Gene ID: 11686, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alox12bprovided by MGI
    Official Full Name
    arachidonate 12-lipoxygenase, 12R typeprovided by MGI
    Primary source
    MGI:MGI:1274782
    See related
    Ensembl:ENSMUSG00000032807 AllianceGenome:MGI:1274782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aloxe2; e-LOX2; 12R-LOX
    Summary
    This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyosiform phenotype. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in stomach adult (RPKM 18.4), lung adult (RPKM 9.8) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Alox12b in Genome Data Viewer
    Location:
    11 B3; 11 42.38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69047898..69060617)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69157072..69169791)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2995 Neighboring gene nuclear encoded tRNA lysine 27 (anticodon TTT) Neighboring gene arachidonate lipoxygenase 3 Neighboring gene arachidonate 8-lipoxygenase Neighboring gene guanylate cyclase 2e Neighboring gene STARR-positive B cell enhancer ABC_E8418

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC130560

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in arachidonate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hepoxilin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hepoxilin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepoxilin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in linoleic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in linoleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipoxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoxygenase pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mucus secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mucus secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein lipidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    arachidonate 12-lipoxygenase, 12R-type
    Names
    12R-lipoxygenase
    epidermis-type lipoxygenase 12
    epidermis-type lipoxygenase 2
    NP_033789.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009659.2NP_033789.1  arachidonate 12-lipoxygenase, 12R-type

      See identical proteins and their annotated locations for NP_033789.1

      Status: REVIEWED

      Source sequence(s)
      AL645527
      Consensus CDS
      CCDS24885.1
      UniProtKB/Swiss-Prot
      O70582
      UniProtKB/TrEMBL
      Q2KHL0
      Related
      ENSMUSP00000035250.3, ENSMUST00000036424.3
      Conserved Domains (2) summary
      cd01753
      Location:2116
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:163681
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69047898..69060617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)