Stx11 syntaxin 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx11provided by MGI
Official Full Name: syntaxin 11provided by MGI
Primary source: MGI:MGI:1921982
See related: Ensembl:ENSMUSG00000039232 AllianceGenome:MGI:1921982
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5830405C08Rik
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within cellular response to type II interferon and leukocyte degranulation. Located in phagocytic vesicle. Is expressed in appendicular skeleton; brain; heart; and pancreas. Used to study familial hemophagocytic lymphohistiocytosis 4. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 4. Orthologous to human STX11 (syntaxin 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 7.1), lung adult (RPKM 6.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A2; 10 4.54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (12813961..12840242, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (12938217..12964498, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.
Title: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.
Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
Title: Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses.
Title: Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages.
required for NK and CD8+ T cell cytotoxicity and neutrophil degranulation
Title: Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.
Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
Title: Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
Blockade of inhibitory receptors on T cells in Stx11-deficient mice converted nonfatal disease course into fatal HLH, identifying T-cell exhaustion as an important factor for determination of disease severity in hemophagocytic lymphohistiocytosis.
Title: Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.
Results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages.
Title: Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages.
Stx11 were highly expressed at the end of fetal development but downregulated at 4 and 11 weeks in brain, pancreas, and heart.
Title: Developmental methylation program and concerted expression of Stx11 in mouse tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

BB274872 (e-PCR)
- UniSTS:208494

NoName (e-PCR)
- UniSTS:488912

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytotoxic T cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: syntaxin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163590.1 → NP_001157062.1 syntaxin-11

See identical proteins and their annotated locations for NP_001157062.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AL691505

Consensus CDS

CCDS48500.1

UniProtKB/Swiss-Prot

Q9D3G5

UniProtKB/TrEMBL

Q3TAS3, Q3U5V8

Related

ENSMUSP00000132758.2, ENSMUST00000163425.9

Conserved Domains (2) summary

pfam00804
Location:41 → 238

Syntaxin

cl22856
Location:207 → 273

SNARE; SNARE motif
NM_001163591.1 → NP_001157063.1 syntaxin-11

See identical proteins and their annotated locations for NP_001157063.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AL691505

Consensus CDS

CCDS48500.1

UniProtKB/Swiss-Prot

Q9D3G5

UniProtKB/TrEMBL

Q3TAS3, Q3U5V8

Conserved Domains (2) summary

pfam00804
Location:41 → 238

Syntaxin

cl22856
Location:207 → 273

SNARE; SNARE motif
NM_029075.1 → NP_083351.1 syntaxin-11

See identical proteins and their annotated locations for NP_083351.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AK017897, AK153408, BY753247

Consensus CDS

CCDS48500.1

UniProtKB/Swiss-Prot

Q9D3G5

UniProtKB/TrEMBL

Q3TAS3, Q3U5V8

Related

ENSMUSP00000046243.6, ENSMUST00000042861.7

Conserved Domains (2) summary

pfam00804
Location:41 → 238

Syntaxin

cl22856
Location:207 → 273

SNARE; SNARE motif